Results 51 to 60 of about 1,197 (161)

Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model. [PDF]

PLoS ONE, 2010
BACKGROUND: The chlamydial proteins CT443 (OmcB) and CT521 (rl16) have previously been identified as human B and/or T cell targets during a chlamydial infection in humans.
Anja Weinreich Olsen, Michael Theisen, Dennis Christensen, Frank Follmann, Peter Andersen   +4 more
doaj   +1 more source

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

Vaccine, 2014
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their own, protein antigens cannot sufficiently induce immune responses in humans, and require the addition of an adjuvant system to ensure appropriate delivery and concomitant immune ...
Dissel, J.T. van, Joosten, S.A., Hoff, S.T., Soonawala, D., Prins, C., Hokey, D.A., O'Dee, D.M., Graves, A., Thierry-Carstensen, B., Andreasen, L.V., Ruhwald, M., Visser, A.W. de, Agger, E.M., Ottenhoff, T.H.M., Kromann, I., Andersen, P.   +15 more
openaire   +3 more sources

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants [PDF]

, 2014
OBJECTIVES: Cationic liposomes of dimethyldioctadecylammonium bromide (DDA) combined with trehalose 6,6'-dibehenate (TDB) elicit strong cell-mediated and antibody immune responses; DDA facilitates antigen adsorption and presentation while TDB potentiates
Bramwell, Vincent W., Christensen, Dennis, Hussain, Mohammed Jubair, Perrie, Yvonne, Wilkinson, Alexander   +4 more
core   +1 more source

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model. [PDF]

PLoS ONE, 2013
BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when ...
Leo Heyndrickx, Guillaume Stewart-Jones, Marianne Jansson, Hanneke Schuitemaker, Emma Bowles, Luigi Buonaguro, Berit Grevstad, Lasse Vinner, Katleen Vereecken, Joe Parker, Meghna Ramaswamy, Priscilla Biswas, Guido Vanham, Gabriella Scarlatti, Anders Fomsgaard, NGIN Consortium   +15 more
doaj   +1 more source

Beyond antigens and adjuvants: formulating future vaccines [PDF]

, 2016
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following ...
Ali, Andrew C. Zmolek, Benson, Boato, Darrell J. Irvine, Desch, Dhodapkar, Dupuis, Garaude, Hanson, Kool, Li, Malyala, Mancini, Pulendran, Ross, Tyson J. Moyer   +16 more
core   +1 more source

Stimulation of Dectin‐1 and Dectin‐2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Induction of a robust and long‐lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize
Alina S. Dzharullaeva, Amir I. Tukhvatulin, Alina S. Erokhova, Alina S. Bandelyuk, Nikita B. Polyakov, Andrey I. Solovyev, Natalia A. Nikitenko, Dmitry V. Shcheblyakov, Boris S. Naroditsky, Denis Y. Logunov, Alexander L. Gintsburg, Manoj K. Mishra   +11 more
wiley   +1 more source

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

Frontiers in Immunology, 2019
Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to ...
Antonella Riccomi, Giovanni Piccaro, Dennis Christensen, Carla Palma, Peter Andersen, Silvia Vendetti   +5 more
doaj   +1 more source

The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection

Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018
T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF‐β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17
Yonghong Li, Chaojun Wei, Hui Xu, Jing Jia, Zhenhong Wei, Rui Guo, Yanjuan Jia, Yu Wu, Yuanting Li, Xiaoming Qi, Zhenhao Li, Xiaoling Gao, Minggang Zhang   +12 more
wiley   +1 more source

Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses

Frontiers in Immunology, 2020
Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants in licensed vaccines, yet their mechanisms are not fully known.
Gabriel Kristian Pedersen, Katharina Wørzner, Peter Andersen, Peter Andersen, Dennis Christensen   +4 more
doaj   +1 more source

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. [PDF]

PLoS ONE, 2009
BackgroundAlthough CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells.
Tara Elvang, Jan P Christensen, Rolf Billeskov, Truc Thi Kim Thanh Hoang, Peter Holst, Allan Randrup Thomsen, Peter Andersen, Jes Dietrich   +7 more
doaj   +1 more source