Results 61 to 70 of about 1,197 (161)
Frontiers in Immunology, 2018 Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable.
Maria Vono +13 more
doaj +1 more source
Mucosal Vaccine Development Based on Liposome Technology
Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016 Immune protection against infectious diseases is most effective if located at the portal of entry of the pathogen. Hence, there is an increasing demand for vaccine formulations that can induce strong protective immunity following oral, respiratory, or genital tract administration.
Valentina Bernasconi +5 more
wiley +1 more source
EBioMedicine, 2018 Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. Here,
Thomas Lindenstrøm +5 more
doaj +1 more source
Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay. [PDF]
, 2019 Secretion of specific proteins contributes to pathogenesis and immune responses in tuberculosis and other bacterial infections, yet the kinetics of protein secretion and fate of secreted proteins in vivo are poorly understood. We generated new monoclonal
Bolz, Miriam +2 more
core +2 more sources
Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets.
Elena Mata +5 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito +9 more
wiley +1 more source
Scientific Reports, 2022 Liposomes are a strong supporting tool in vaccine technology, as they are a versatile system that not only act as antigen delivery systems but also adjuvants that can be highly effective at stimulating both innate and adaptive immune responses.
Laura A. J. Feather +5 more
doaj +1 more source
Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein : a multivariate analysis study [PDF]
, 2015 OBJECTIVE: In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis.
Bramwell, Vincent W. +4 more
core +1 more source
Tuberculosis Research and Treatment, Volume 2011, Issue 1, 2011., 2011 Mycobacterium bovis bacille Calmette‐Guérin (BCG) is the only available vaccine for tuberculosis (TB). Although this vaccine is effective in controlling infantile TB, BCG‐induced protective effects against pulmonary diseases in adults have not been clearly demonstrated.
Kazuhiro Matsuo +2 more
wiley +1 more source
PLoS ONE, 2018 There is a need for the rational design of safe and effective vaccines to protect against chronic bacterial pathogens such as Mycobacterium tuberculosis and Mycobacterium avium subsp. paratuberculosis in a number of species.
Aneesh Thakur +6 more
doaj +1 more source