Results 21 to 30 of about 3,383 (174)

Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity

Molecules, 2017
Glioblastoma multiforme (GBM) is an aggressive brain tumor that correlates with short patient survival and for which therapeutic options are limited. Polyphenolic compounds, including caffeic acid phenethyl ester (CAPE, 1a), have been investigated for ...
Pier Morin, Patrick-Denis St-Coeur, Jérémie A. Doiron, Marc Cormier, Julie J. Poitras, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application [PDF]

Pharmacia, 2019
Caffeic acid phenethyl ester (CAPE) is the major pharmacologically-active component of some propolis types, rich in polyphenols, such as poplar propolis types.
Yordan Yordanov
doaj   +3 more sources

Caffeic Acid Phenethyl Ester Inhibits Endothelial Tissue Factor Expression

Biological and Pharmaceutical Bulletin, 2013
Caffeic acid phenethyl ester (CAPE) is a component of honeybee hives with various beneficial properties. Tissue factor (TF), the key trigger of thrombosis, is expressed in human endothelial cells. This study was designed to investigate whether CAPE modulates TF expression in human aortic endothelial cells (HAECs). Western blots and real-time polymerase
Cathérine, Gebhard, Barbara Elisabeth, Stähli, Stephanie, Largiadèr, Erik Walter, Holy, Alexander, Akhmedov, Giovanni Guido, Camici, Thomas Felix, Lüscher, Felix Christoph, Tanner   +7 more
openaire   +3 more sources

Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury [PDF]

Brain, 2004
Neonatal hypoxic-ischaemic (HI) brain injury resulting in encephalopathy is a leading cause of morbidity and mortality with no effective treatment. Here we show that caffeic acid phenethyl ester (CAPE), an active component of propolis, administered either before or after an HI insult, significantly prevents HI-induced neonatal rat brain damage in the ...
Xing, Wei, Liming, Zhao, Zhizhong, Ma, David M, Holtzman, Chong, Yan, Richard C, Dodel, Harald, Hampel, Wolfgang, Oertel, Martin R, Farlow, Yansheng, Du   +9 more
openaire   +2 more sources

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

Mediators of Inflammation, 2017
Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis
Luc H. Boudreau, Grégoire Lassalle-Claux, Marc Cormier, Sébastien Blanchard, Marco S. Doucet, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

Standardization, anti-carcinogenic potential and biosafety of Indian propolis

Journal of Ayurveda and Integrative Medicine, 2019
Background: Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE).
Harshad Kapare, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik   +3 more
doaj   +1 more source

Caffeic Acid Phenethyl Ester Alleviates Mesenteric Ischemia/Reperfusion Injury

Journal of Investigative Surgery, 2012
We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on intestinal mucosal injury induced by superior mesenteric occlusion.This experimental study was conducted on 48 male Wistar-albino rats. The animals were randomly allocated into four groups: (i) Sham-operated group, laparotomy without intestinal ischemia/reperfusion (IR ...
AKOGLU, Musa, Simsek, Nilufer Genc, Sacar, MUSTAFA, Yenisey, Cigdem, BOSTANCI, Erdal Birol, Teke, Zafer   +5 more
openaire   +3 more sources

Activity of Caffeic Acid Phenethyl Ester in Caenorhabditis Elegans [PDF]

Future Medicinal Chemistry, 2016
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans.
Jeffrey J, Coleman, Tomomi, Komura, Julia, Munro, Michael P, Wu, Rakhee R, Busanelli, Angela N, Koehler, Méryl, Thomas, Florence F, Wagner, Edward B, Holson, Eleftherios, Mylonakis   +9 more
openaire   +2 more sources

Caffeic acid phenethyl ester inhibits liver fibrosis in rats

World Journal of Gastroenterology, 2015
To investigate the hepatoprotective effects and antioxidant activity of caffeic acid phenethyl ester (CAPE) in rats with liver fibrosis.A total of 75 male Sprague-Dawley rats were randomly assigned to seven experimental groups: a normal group (n = 10), a vehicle group (n = 10), a model group (n = 15), a vitamin E group (n = 10), and three CAPE groups ...
Mei, Li, Xiu-Fang, Wang, Juan-Juan, Shi, Ya-Ping, Li, Ning, Yang, Song, Zhai, Shuang-Suo, Dang   +6 more
openaire   +2 more sources

Caffeic Acid Phenethyl Ester Loaded Electrospun Nanofibers for Wound Dressing Application

Journal of Pharmaceutical Sciences, 2022
Electrospinning is an advantageous method with a wide usage area, which enables the production of materials consisting of nano-thickness fibers. In this study, caffeic acid phenethyl ester (CAPE) molecule was loaded onto the poly(lactic-co-glycolic acid) (PLGA) nanofibers and obtained nanofibers were physicochemically and biologically investigated for ...
Seçil Kaya, Duygu Elif Yilmaz, Ilkgül Akmayan, Ozlem Egri, Tülin Arasoglu, Serap Derman   +5 more
openaire   +4 more sources