Results 51 to 60 of about 662,429 (302)

Oral lichen planus: comparative efficacy and treatment costs—a systematic review

BMC Oral Health, 2022
Objective To compare the reported efficacy and costs of available interventions used for the management of oral lichen planus (OLP). Materials and methods A systematic literature search was performed from database inception until March 2021 in MEDLINE ...
Shaiba Sandhu, Brittany A. Klein, Malak Al-Hadlaq, Prazwala Chirravur, Amal Bajonaid, Yuanming Xu, Rossella Intini, Mai Hussein, Piamkamon Vacharotayangul, Herve Sroussi, Nathaniel Treister, Stephen Sonis   +11 more
doaj   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer ...
Hube Bernhard, Wilson Duncan, Duncan Wilson, Bernhard Hube, Mayer, François L, Hube, Bernhard, Mayer François L., Wilson, Duncan, François L Mayer   +8 more
core   +2 more sources

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Calcineurin and Systemic Lupus Erythematosus: The Rationale for Using Calcineurin Inhibitors in the Treatment of Lupus Nephritis

, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a broad spectrum of clinical presentations that can affect almost all organ systems.
Samuel Garcia, Coral Mourino Rodríguez, Carlos Rafael-Vidal, Nair Pérez, Jose M. Pego-Reigosa, Irene Altabás   +5 more
core   +1 more source

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

mBio, 2021
Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting ...
Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer   +7 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis

, 2014
Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans
Dimitrios P. Kontoyiannis, Fazal Shirazi
core   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +2 more sources