Results 41 to 50 of about 662,429 (302)

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
The Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a crucial role in gene expression in different cell types such as T-lymphocytes, cardiac myocytes, and smooth muscle cells.
Fresu, Luigia, Ashby, Dominique S, Freeman, Tom C, Genazzani, Armando A, Kramer, Dana   +4 more
core  

Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus

, 2011
Michael SticherlingHautklinik, Universitätsklinikum Erlangen (Clinic of Dermatology, University Hospitals of Erlangen), Erlangen, GermanyAbstract: Cutaneous manifestations of lupus erythematosus (CLE) are manifold, presenting with unspecific ...
Michael Sticherling
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Resolution of Hypokalemia and Hypotension With Tacrolimus and Extrarenal Transplantation in Gitelman Syndrome

Annals of Internal Medicine: Clinical Cases
Gitelman syndrome (GS) is characterized by genetic mutations in the sodium chloride cotransporter (NCC), leading to renal potassium, sodium, and magnesium wasting.
Halee Yue, Martina Cacciapuoti, Jennefer Carter, Vivek Bhalla   +3 more
doaj   +1 more source

Clathrin-independent but dynamin-dependent mechanisms mediate Ca2+-triggered endocytosis of the glutamate GluK2 receptor upon excitotoxicity [PDF]

Journal of Integrative Neuroscience, 2020
We first explore the features of GluK2 endocytosis during kainate excitotoxicity and then explore the role of Ca2+ in the regulation of GluK2 endocytosis. The roles of Ca2+ were examined by treating cells with Ca2+ inhibitors or chelators.
Jing-Jing Du, Lu Yan, Wei Zhang, Hao Xu, Qiu-Ju Zhu
doaj   +1 more source

Calcineurin in cancer signaling networks [PDF]

Calcium/calcineurin/nuclear factor of activated T-cell signaling is a vital regulator of the development and function of immune, nervous, cardiovascular, and musculoskeletal systems.
Tsubota, Shomas, Haba, Honoka, Shimada, Midori   +2 more
core   +1 more source

Multiple labial melanotic macules occurring after topical application of calcineurin inhibitors [PDF]

, 2014
Topical calcineurin inhibitors are widely used to treat inflammatory dermatoses for their steroid-sparing advantage. Herein, we report a patient with chronic lip dermatitis who developed multiple labial melanotic macules after application of tacrolimus 0.
Shi, Vivian Y, Joo, Jayne S, Sharon, Victoria R   +2 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study

Frontiers in Pharmacology
IntroductionOral lichen planus (OLP) is a chronic inflammatory condition with malignant potential for oral squamous cell carcinoma (OSCC). Differential risks of pharmacological treatments, particularly long-term use, remain unclear.
Christian Seebauer, Christian Seebauer, Ralf Ludwig, Ralf Ludwig, Ralf Ludwig, Peter Sieg, Henning Olbrich, Philip Curman, Philip Curman, Philip Curman, Philip Curman   +10 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source