Results 31 to 40 of about 662,429 (302)
Selective Targeting of Calcineurin Isoforms by Calcineurin Inhibitors
The FASEB Journal, 2021 Background Calcineurin inhibitors (CNIs) have increased one‐year and five‐year post‐transplantation survival rates to ~90% and ~75%, respectively. While CNIs have dramatically improved the quality of patient care, their side effects are also noteworthy: long‐term CNI therapy is nephrotoxic and is a growing ...
Adaku Ume, Clintoria Williams
openaire +1 more source
A high-throughput screen to identify novel calcineurin inhibitors
, 2012 Calcineurin is a eukaryotic protein phosphatase important for many signalling and developmental processes in cells. Inhibitors of this enzyme are used clinically and there is interest in identifying novel inhibitors for therapeutic applications.
Kennedy, J. +4 more
core +2 more sources
RCAN-11R peptide provides immunosuppression for fully mismatched islet allografts in mice
Scientific Reports, 2017 Calcineurin inhibitors have been used for transplant therapy. However, the inhibition of calcineurin outside the immune system has a number of side effects.
Hirofumi Noguchi +7 more
doaj +1 more source
mBio, 2017 The genus Malassezia includes yeasts that are commonly found on the skin or hair of animals and humans as commensals and are associated with a number of skin disorders.
Giuseppe Ianiri +3 more
doaj +1 more source
Трансплантология (Москва), 2021 Introduction. One of the serious complications after transplantation of solid organs and bone marrow is the development of post-transplant lymphoproliferative diseases.Clinical case.
V. E. Syutkin +5 more
doaj +1 more source
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus
, 2007 Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus.
Joseph Heitman +13 more
core +1 more source
EMBO Molecular Medicine, 2015 Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection.
Susanne Herbst +10 more
doaj +1 more source
Atopic dermatitis in children. A current algorithm for the disease treatment and control
Vestnik Dermatologii i Venerologii, 2017 The article discusses key aspects of the pathogenesis of atopic dermatitis and issues of the selection of pathogenetically substantiated therapy methods.
D. V. Proshutinskaya
doaj +1 more source
Calcineurin Inhibitors in Liver Transplantation: To Be or Not to Be
Transplantation Proceedings, 2011 Orthotopic liver transplantation is currently the procedure of choice for patients with end-stage liver disease, with survival rates greater than 90% and 80% at 1 and 5 years, respectively. These excellent results are largely due to knowledge of the natural history of liver diseases, improved surgical techniques and postoperative management of ...
Molina Perez, Esther +2 more
openaire +3 more sources
Immunosuppressive drugs and their aerosol delivery for COVID-19 treatment
Фундаментальная и клиническая медицина, 2022 Despite numerous efforts of healthcare, the incidence of COVID-19 and its fatal complications remains unacceptably high. As COVID-19 pathophysiology is notable for an uncurbed immune response, its treatment protocols routinely include immunosuppressive ...
V. I. Kobylyansky
doaj +1 more source