Results 11 to 20 of about 662,429 (302)
Frontiers in PharmacologyCalcineurin is a serine/threonine phosphatase that classically regulates T cell activation and modulates immune response by targeting transcription factors of the NFaT family.
Alexander Nolze, Claudia Grossmann
doaj +2 more sources
Linchuang shenzangbing zazhi, 2015 Objective To observe the efficacy of calcineurin inhibitors in the treatment of the simple and the refractory idiopathic membranous nephropathy.Methods Seventy-two patients with idiopathic membranous nephropathy and regularly followed up in Changzheng ...
CUI Lin-lin, YE Chao-yang
doaj +1 more source
On the interchangeability of calcineurine inhibitors
Безопасность и риск фармакотерапии, 2018 Calcineurin inhibitors, cyclosporine and tacrolimus, are the main immunosuppressants used in solid organ transplantation, but the peculiarities of their pharmacokinetics allow to classify them to a group of medicines with a narrow therapeutic range ...
K. E. Zatolochina +6 more
doaj +1 more source
Calcineurin Inhibitors and COVID-19. [PDF]
Reumatol Clin (Engl Ed), 2022 Hage R, Schuurmans MM.
europepmc +7 more sources
Calcineurin Inhibitor Nephrotoxicity [PDF]
Clinical Journal of the American Society of Nephrology, 2009 The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens.
Maarten, Naesens +2 more
openaire +2 more sources
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]
, 2012 The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P. +10 more
core +2 more sources
Calcineurin Inhibitor Toxicity in Solid Organ Transplantation [PDF]
, 2021 Calcineurin inhibitors (CNIs) have a substantial role in maintaining immunosuppression after solid organ transplantation (SOT). These drugs have a narrow therapeutic window, and individual doses and drug treatment monitoring are necessary.
Vera Genitsch +5 more
core +1 more source
Allograft Survival with Calcineurin Inhibitors [PDF]
, 2008 The immunosuppressive drugs cyclosporine A (CsA) and tacrolimus (FK506), also called calcineurin inhibitors, have truly revolutionized allograft transplantation.
Esther Voegelin +3 more
core +1 more source
, 2023 Background: Ototoxicity is a side effect of drugs and medications that usually leads to bilateral and symmetric sensorineural hearing loss that commonly affects the high-frequency range initially, with or preceded by tinnitus.
Oyarzún,Javier +5 more
core +2 more sources
Treatment of myasthenia gravis patients with calcineurin inhibitors in Japan: A retrospective analysis of outcomes [PDF]
, 2015 Objectives Calcineurin inhibitors (CNI) are approved for the treatment of myasthenia gravis (MG) in Japan. However, the extent to which CNI have been effective remains unclear. Here we report data regarding CNI use and outcomes of MG.
Shigeaki Suzuki +13 more
core +1 more source