Results 1 to 10 of about 44,570 (118)

Neurotoxicity of Calcineurin Inhibitors [PDF]

Annals of Indian Academy of Neurology
Cyclosporine and tacrolimus belong to the immunosuppressive drugs of the calcineurin inhibitors group. They are widely used in the treatment of patients after organ transplants. One of their complications is neurotoxicity, the mechanism of which is still
Aleksander Bajon, Jędrzej Sikora, Michal Siwek, Julia Wiecanowska, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka, Anna Mania   +6 more
doaj   +2 more sources

Calcineurin Inhibitors and Uric Acid Control in Solid Organ Transplantation: A Systematic Review [PDF]

Medical Sciences
Background/Objectives: Asymptomatic hyperuricemia has been associated with increased cardiovascular risk; it is related to factors such as diet, genetic predisposition, and drug-related side effects.
Francesca K. Martino, Marco Bogo, Ludovica Brunetta, Francesca Fioretti, Leda Cattarin, Lucia F Stefanelli, Federico Nalesso   +6 more
doaj   +2 more sources

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides

mBio, 2020
Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales.
Sandeep Vellanki, R. Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee   +7 more
doaj   +1 more source

Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury. [PDF]

PLoS ONE, 2016
The calcineurin inhibitors cyclosporine A (CsA) and tacrolimus are widely used in the treatment of proteinuria diseases. As the direct target of these drugs, calcineurin has previously been demonstrated to play a role in proteinuria diseases.
Fangrui Ding, Xuejuan Li, Baihong Li, Jifan Guo, Yanqin Zhang, Jie Ding   +5 more
doaj   +1 more source

Current options and perspectives for the topical treatment of atopic dermatitis

Przegląd Dermatologiczny, 2021
Atopic dermatitis is one of the most common chronic and recurrent skin conditions, characterized by a complex genetic background, most commonly occurring in children. Its prevalence is still increasing.
Roman Nowicki, Elżbieta Grubska-Suchanek, Magdalena Trzeciak, Aleksandra Wilkowska   +3 more
doaj   +1 more source

Diagnosis and treatment of calcineurin inhibitor-induced pain syndrome in chronic Kidney disease Stage 5 transplantation

Indian Journal of Transplantation, 2018
Context: Musculoskeletal pain is a frequent manifestation in postrenal transplant recipients that caused by several diseases. Clinically used calcineurin inhibitors including cyclosporine A and tacrolimus can induce calcineurin inhibitor-induced bone ...
Fateme Shamekhi Amiri
doaj   +1 more source

Calcineurin inhibitors in steroid and anti‐TNF‐alpha refractory immune checkpoint inhibitor colitis

JGH Open, 2021
Background and Aim Immune checkpoint inhibitor (ICI) colitis is an increasingly common problem encountered as the use of checkpoint inhibitors (CPIs) grows in the management of cancers.
Eva Zhang, Christopher Kiely, Neomal Sandanayake, Stephen Tattersall   +3 more
doaj   +1 more source

Targeted Inhibition of Pancreatic Acinar Cell Calcineurin Is a Novel Strategy to Prevent Post-ERCP PancreatitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: There is a pressing need to develop effective preventative therapies for post–endoscopic retrograde cholangiopancreatography pancreatitis (PEP).
Abrahim I. Orabi, Li Wen, Tanveer A. Javed, Tianming Le, Ping Guo, Subramaniam Sanker, David Ricks, Kristy Boggs, John F. Eisses, Carlos Castro, Xiangwei Xiao, Krishna Prasadan, Farzad Esni, George K. Gittes, Sohail Z. Husain   +14 more
doaj   +1 more source

Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells. [PDF]

PLoS ONE, 2012
Receptor desensitization is a ubiquitous regulatory mechanism that defines the activatable pool of receptors, and thus, the ability of cells to respond to environmental stimuli. In recent years, the molecular mechanisms controlling the desensitization of
Michelle B Henesy, Andrea L Britain, Bing Zhu, Lauren Amable, Richard E Honkanen, Jackie D Corbin, Sharron H Francis, Thomas C Rich   +7 more
doaj   +1 more source

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Cell Communication and Signaling, 2009
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than ...
Baumgrass Ria, Sieber Matthias
doaj   +1 more source