Results 21 to 30 of about 654,231 (380)
Structural insights on TRPV5 gating by endogenous modulators. [PDF]
, 2018 TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5.
Carnevale, Vincenzo +11 more
core +3 more sources
Presynaptic calcium channels [PDF]
Neuroscience Research, 2018 Presynaptic Ca2+ entry occurs through voltage-gated Ca2+ (CaV) channels which are activated by membrane depolarization. Depolarization accompanies neuronal firing and elevation of Ca2+ triggers neurotransmitter release from synaptic vesicles. For synchronization of efficient neurotransmitter release, synaptic vesicles are targeted by presynaptic Ca2 ...
openaire +4 more sources
eLife, 2014 TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons.
Jason Tien +6 more
doaj +1 more source
Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Frontiers in Pharmacology, 2018 As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes.
Yuhuan Luo +4 more
doaj +1 more source
Calcium oscillation on homogeneous and heterogeneous networks of ryanodine receptor [PDF]
, 2022 Calcium oscillation is an important calcium homeostasis, imbalance of which is the key mechanism of initiation and progression of many major diseases. The formation and maintenance of calcium homeostasis are closely related to the spatial distribution of calcium channels.
arxiv +1 more source
Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]
ACS Applied Materials & Interfaces Manuscript ID:
am-2021-004953.R2, 2021 Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv +1 more source
Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking [PDF]
, 2018 Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the ...
Chen, Xingjuan +10 more
core +1 more source
Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides [PDF]
, 2011 : Modulation of presynaptic voltage-dependent Ca+ channels is a major means of controlling neurotransmitter release. The CaV 2.2 Ca2+ channel subunit contains several inhibitory interaction sites for Gβγ subunits, including the amino terminal (NT) and I ...
Agler +53 more
core +2 more sources
Regulation of store-operated calcium entry [PDF]
arXiv, 2023 Plasma membrane calcium influx through ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors in the endoplasmic reticulum (ER) to release calcium pools from the ER lumen.
arxiv
Calcium Channel Blocker Overdose Simulation
MedEdPORTAL, 2015 Introduction Accidental poisoning and drug overdose are a common occurrence in the emergency medicine setting. Often it is unknown what substances the patient has taken.
Michael Maniaci +2 more
doaj +1 more source