Results 21 to 30 of about 346,127 (305)
The roles of the subunits in the function of the calcium channel [PDF]
, 1991 Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha ...
Biel, Martin +5 more
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Physiology, 2017 In this review article, we discuss the different gene products and translational variants of ORAI proteins and their contribution to the makeup of different native calcium-conducting channels with distinct compositions and modes of activation. We also review the different modes of regulation of these distinct calcium channels and their impact on ...
Mohamed, Trebak, James W, Putney
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eLife, 2014 TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons.
Jason Tien +6 more
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Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement
Cell Reports, 2020 Summary: The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated chloride channel TMEM16A.
Kayla N. Berry, Tom J. Brett
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Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Frontiers in Pharmacology, 2018 As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes.
Yuhuan Luo +4 more
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MODULATION OF THE CGMP-GATED CHANNEL BY CALCIUM [PDF]
, 1995 Calcium acting through calmodulin has been shown to regulate the affinity of cyclic nucleotide-gated channels expressed in cell lines.
LAGNADO, L, SAGOO, MS
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Calcium Channel Blocker Overdose Simulation
MedEdPORTAL, 2015 Introduction Accidental poisoning and drug overdose are a common occurrence in the emergency medicine setting. Often it is unknown what substances the patient has taken.
Michael Maniaci +2 more
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An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2010 The large conductance, voltage- and calcium-dependent potassium (BK) channel serves as a major negative feedback regulator of calcium-mediated physiological processes and has been implicated in muscle dysfunction and neurological disorders.
Linu S Abraham +4 more
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Activation of Calcium Channels
Biophysical Journal, 1984 Activation of Ca channels has been described as a Hodgkin-Huxley process in which the time constants have ratios of two or greater (1, 2, 3) or as a three-state linear sequential process with two very different time constants (4). We examined activation by measuring the turn-on and turn-off of macroscopic Ca currents and the discharge of single Ca ...
Brown, Arthur M. +2 more
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Vacuolar calcium channels [PDF]
Journal of Experimental Botany, 2007 The central vacuole is the largest Ca2+ store in a mature plant cell. Ca2+ release from this store contributes to Ca2+-mediated intracellular signalling in a variety of physiological responses. However, the routes for vacuolar Ca2+ release are not well characterized.
I I, Pottosin, G, Schönknecht
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