Results 131 to 140 of about 149 (148)
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Calcium signaling in platelets
Journal of Thrombosis and Haemostasis, 2009Agonist-induced elevation in cytosolic Ca2+ concentrations is essential for platelet activation in hemostasis and thrombosis. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane (PM). Ca2+ store release is a well-established process involving phospholipase (PL)C-mediated production of inositol-1,4,5 ...
David Varga-Szabo +2 more
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Calcium and signal transduction
Biochemistry and Molecular Biology Education, 2008AbstractCell signaling is an essential process in which a variety of external signals, defined as first messengers, are translated inside the cells into specific responses, which are mediated by a less numerous group of second messengers. The exchange of signals became a necessity when the transition from monocellular to pluricellular life brought with
Fedrizzi, Laura +2 more
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Trends in Neurosciences, 1988
very cell in an organism has a specialized task or function. As investigators, we are constantly posing the questions 'How is this function carried out? How is it regulated?' It is now a fundamental tenet of modem biology that small diffusible second messen- ger molecules act within the cell to provide a link between stimulus and output.
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very cell in an organism has a specialized task or function. As investigators, we are constantly posing the questions 'How is this function carried out? How is it regulated?' It is now a fundamental tenet of modem biology that small diffusible second messen- ger molecules act within the cell to provide a link between stimulus and output.
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The Language of Calcium Signaling
Annual Review of Plant Biology, 2010Ca2+ signals are a core regulator of plant cell physiology and cellular responses to the environment. The channels, pumps, and carriers that underlie Ca2+ homeostasis provide the mechanistic basis for generation of Ca2+ signals by regulating movement of Ca2+ ions between subcellular compartments and between the cell and its extracellular environment ...
Dodd, Antony N. +2 more
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Cell Calcium, 2005
In hepatocytes, hormones linked to the formation of the second messenger inositol 1,4,5-trisphosphate (InsP3) evoke transient increases or spikes in cytosolic free calcium ([Ca2+]i), that increase in frequency with the agonist concentration. These oscillatory Ca2+ signals are thought to transmit the information encoded in the extracellular stimulus to ...
Lawrence D. Gaspers, Andrew P. Thomas
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In hepatocytes, hormones linked to the formation of the second messenger inositol 1,4,5-trisphosphate (InsP3) evoke transient increases or spikes in cytosolic free calcium ([Ca2+]i), that increase in frequency with the agonist concentration. These oscillatory Ca2+ signals are thought to transmit the information encoded in the extracellular stimulus to ...
Lawrence D. Gaspers, Andrew P. Thomas
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Biochemical Society Transactions, 2003
Calcium regulates three different aspects of cardiac contraction. It drives pacemaker activity, excitation–contraction coupling and the transcriptional events that remodel the Ca2+ signalling system in both health and disease.
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Calcium regulates three different aspects of cardiac contraction. It drives pacemaker activity, excitation–contraction coupling and the transcriptional events that remodel the Ca2+ signalling system in both health and disease.
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Mechanosensory Calcium Signaling
2012Mechanotransduction describes the cellular process by which mechanical stimuli are translated into intracellular adaptive responses through biochemical signals. Current research has begun to focus on the once-forgotten organelle, the primary cilia, in this mechanotransduction process. Primary cilia are found on almost every cell type, with a functional
Surya M. Nauli +3 more
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Calcium signaling and apoptosis
Biochemical and Biophysical Research Communications, 2003Ca(2+) is one of the key regulators of cell survival, but Ca(2+) can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca(2+) are mediated by a diverse range of Ca(2+)-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria.
György Hajnóczky +2 more
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2012
Ca2+ is an important signal transduction molecule that has been shown to regulate responses to a large number of environmental stimuli in plants and control many developmental processes. These stimuli induce the formation of Ca2+ signals within a cell, which are generated through the action of Ca2+ release and uptake from and into internal cellular ...
Bickerton, P.D., Pittman, J.K.
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Ca2+ is an important signal transduction molecule that has been shown to regulate responses to a large number of environmental stimuli in plants and control many developmental processes. These stimuli induce the formation of Ca2+ signals within a cell, which are generated through the action of Ca2+ release and uptake from and into internal cellular ...
Bickerton, P.D., Pittman, J.K.
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Calcium Signalling in the Endothelium
2006Elevations in cytosolic Ca2+ concentration are the usual initial response of endothelial cells to hormonal and chemical transmitters and to changes in physical parameters, and many endothelial functions are dependent upon changes in Ca2+ signals produced.
Hiroshi Watanabe, Quang-Kim Tran
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