Results 131 to 140 of about 6,142,205 (404)
Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice [PDF]
, 2000 Dysregulation of calcium signaling has been causally implicated in brain aging and Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the leading cause of autosomal dominant familial Alzheimer's disease (FAD), cause highly specific ...
Akbari, Yama +5 more
core +1 more source
Calcium Signaling and Cardiac Arrhythmias.
Circulation Research, 2017 There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca2+) ions mediate various types of cardiac arrhythmias.
A. P. Landstrom, D. Dobrev, X. Wehrens
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Journal of Biomechanical Science and Engineering, 2018 Osteoblasts change their intracellular calcium ion concentration in response to mechanical stimuli. Although it has been reported that osteoblasts sense and respond to stretching of a substrate on which osteoblastic cells have adhered, the details of the
Katsuya SATO +4 more
doaj +1 more source
Maxwell's demon for calcium binding to calmodulin? [PDF]
arXiv, 2013 In the recent paper (2011) Faas and co-workers claimed that calmodulin could directly detect Ca2+ signals by acting as extremely fast calcium buffer. However the results and their interpretation raise serious doubts about this conclusion.
arxiv
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
MULTISCALE COMPLEXITY OF CALCIUM SIGNALING: MODELING ANGIOGENESIS [PDF]
, 2012 Intracellular calcium signaling is a universal, evolutionary conserved and versatile regulator of cell biochemistry. The complexity of calcium signaling and related cell machinery can be investigated by the use of experimental strategies, as well as by ...
Munaron L., SCIANNA, MARCO
core +1 more source
Adhesion-driven patterns in a calcium-dependent model of cancer cell movement [PDF]
arXiv, 2020 Cancer cells exhibit increased motility and proliferation, which are instrumental in the formation of tumours and metastases. These pathological changes can be traced back to malfunctions of cellular signalling pathways, and calcium signalling plays a prominent role in these.
arxiv
HNCcorr: A Novel Combinatorial Approach for Cell Identification in Calcium-Imaging Movies [PDF]
, 2017 Calcium imaging has emerged as a workhorse method in neuroscience to investigate patterns of neuronal activity. Instrumentation to acquire calcium imaging movies has rapidly progressed and has become standard across labs. Still, algorithms to automatically detect and extract activity signals from calcium imaging movies are highly variable from~lab~to ...
arxiv +1 more source
Glia, 2016 Regulatory volume decrease (RVD) is a process by which cells restore their original volume in response to swelling. In this study, we have focused on the role played by two different Aquaporins (AQPs), Aquaporin‐4 (AQP4), and Aquaporin‐1 (AQP1), in ...
M. G. Mola +7 more
semanticscholar +1 more source