Results 41 to 50 of about 518,632 (310)

Force-Regulated Calcium Signaling of Lymphoid Cell RPMI 8226 Mediated by Integrin α₄β₇/MAdCAM-1 in Flow

Biomolecules, 2023
MAdCAM-1 binds to integrin α4β7, which mediates the rolling and arrest of circulating lymphocytes upon the vascular endothelia during lymphocytic homing.
Dongshan Sun, Zhiqing Luo, Ying Kong, Ruiting Huang, Quhuan Li   +4 more
doaj   +1 more source

Cellular and nuclear morphology…and calcium signaling: revealing the interplay between structure and function

, 2012
Poster presentation: Calcium plays a pivotal role in relaying electrical signals of the cell to subcellular compartments, such as the nucleus. Since this one ion type is used by the cell for many processes a neuron needs to establish finely tuned calcium
Queisser, Sean Gillian, Hagenston, Anna, Breit, Markus, Bengtson, Peter von der, Bading, Hilmar   +4 more
core   +1 more source

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]

, 2011
Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
Marco Scianna, Scianna, Marco
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transition from stochastic to deterministic behavior in calcium oscillations [PDF]

, 2005
Simulation and modeling is becoming more and more important when studying complex biochemical systems. Most often, ordinary differential equations are employed for this purpose.
Green, Anne K., Kummer, U., Ursula Kummer, C. Jane Dixon, Marhl, Marko, Pahle, J., Krajnc, Borut, Pahle, Jürgen, Dixon, C. Jane, Kummer, Ursula, Marko Marhl, Jürgen Pahle, Kummer, U. (Ursula), Borut Krajnc, Green, A. K., Anne K. Green, Dixon, C. J., Marhl, M., Krainc, B.   +18 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

Neurobiology of Disease
Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists
Charlene P. Poore, Nurul A.M.N. Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Liao   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The involvement of calcium carriers and of the vacuole in the glucose-induced calcium signaling and activation of the plasma membrane H+-ATPase in Saccharomyces cerevisiae cells.

, 2012
Previous work from our laboratories demonstrated that the sugar-induced activation of plasma membrane H+-ATPase in Saccharomyces cerevisiae is dependent on calcium metabolism with the contribution of calcium influx from external medium.
Tisi, Renata, E.M.C. Ribeiro, Bouillet, L. E. M., E. Perovano, R. Tisi, Martegani, Enzo, Trópia, Maria José Magalhães, Cardoso, A. S., M.J.M. Trópia, R.R. Pereira, Tisi, R., Fietto, Luciano Gomes, Brandão, Rogélio Lopes, Ribeiro, E. M. C., Pereira, R. R., Trópia, M. J. M., Brandão, R. L., R.L. Brandão, L.G. Fietto, L.E.M. Bouillet, E. Martegani, I.M. Castro, Perovano, Eduardo, Fietto, L. G., Castro, I. M., Cardoso, Anamaria de Souza, Bouillet, Leoneide Érica Maduro, Perovano, E., A.S. Cardoso, Castro, Ieso de Miranda, Martegani, E., Ribeiro, Erica Milena de Castro   +31 more
core   +1 more source

Calcium Signalling in Pericytes [PDF]

Journal of Vascular Research, 2014
Recent advances in pericyte research have contributed to our understanding of the physiology and pathophysiology of microvessels. The microvasculature consists of arteriolar and venular networks located upstream and downstream of the capillaries.
Theodor, Burdyga, Lyudmyla, Borysova
openaire   +2 more sources