Results 21 to 30 of about 26,870 (178)
Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
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Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. [PDF]
PLoS Genetics, 2010 Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are ...
Shoji Hata +7 more
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Neoplasia: An International Journal for Oncology Research, 2004 Several oncogene and tumor-suppressor gene products are known substrates for the calpain family of cysteine proteases, and calpain is required for transformation by v-src and tumor invasion.
N.O. Carragher, B.D. Fonseca, M.C. Frame
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M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
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Skeletal Muscle, 2020 Background Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging.
Clayton Whitmore +11 more
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Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease. [PDF]
PLoS ONE, 2015 Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca2+.
Monica Averna +7 more
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Cells, 2022 Mechanical ventilation (MV) is a clinical tool that provides respiratory support to patients unable to maintain adequate alveolar ventilation on their own.
Hayden W. Hyatt +3 more
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Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade
BMC Complementary Medicine and Therapies, 2021 Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding +5 more
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Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury
Biochemistry and Biophysics ReportsCalpains are calcium-dependent cysteine proteases activated by intracellular Ca2+. Although calpains mainly exist in the cytosol, calpain-13 is present in the mitochondria in mouse brains; however, the enzymatic properties and physiological functions of ...
Yusaku Chukai +5 more
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Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer
Frontiers in Genetics, 2019 As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis.
Ze-Xian Liu +10 more
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