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Increased campesterol synthesis by improving lipid content in engineered Yarrowia lipolytica

Applied Microbiology and Biotechnology, 2020
Sterols attract increasing attention due to their important bioactivities. The oleaginous yeast Yarrowia lipolytica has large lipid droplets, which provide storage for the accumulated steroid compounds. In this study, we have successfully constructed a campesterol biosynthetic pathway by modifying the synthetic pathway of ergosterol in Y.
Ching Yuan Hu, Yonghong Meng
exaly   +3 more sources

Plasma Lathosterol and Campesterol in Detection of Ileal Dysfunction

Scandinavian Journal of Gastroenterology, 1988
Plasma lathosterol levels reflect cholesterol synthesis, especially that induced by bile acid malabsorption, whereas plasma plant sterol contents change in parallel with cholesterol and fat absorption. The significance of lathosterols and plant sterols (campesterol and sitosterol) was therefore studied in detection of ileal dysfunction in 29 patients ...
M A, Färkkilä, T A, Miettinen
exaly   +3 more sources

Improved campesterol production in engineered Yarrowia lipolytica strains

Biotechnology Letters, 2017
To engineer Yarrowia lipolytica for improving the heterologous production of campesterol (a key precursor to manufacture pharmaceutical steroids).By screening 7-dehydrocholesterol reductase (DHCR7) from diverse species, DHCR7 from Danio rerio was the best candidate for campesterol synthesis.
Wen-Hai Xiao, Ying-Jin Yuan
exaly   +3 more sources

New glycosides of the campesterol derivative from the rhizomes of Tacca chantrieri

Steroids, 2005
Seven new glycosides of the campesterol derivative (24R,25S)-ergost-5-ene-3beta,26-diol (1-7) were isolated from the rhizomes of Tacca chantrieri (Taccaceae). Their structures were determined by extensive spectroscopic analysis, including 2D NMR data, and a few chemical transformations.
Akihito Yokosuka
exaly   +3 more sources

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