Results 91 to 100 of about 14,945 (175)

Experience of the Successful Treatment With Canakinumab of a Patient With Systemic Juvenile Idiopathic Arthritis

Вопросы современной педиатрии, 2017
The article presents the follow-up of a patient with severe systemic juvenile idiopathic arthritis (JIA) resistant to glucocorticosteroids, to the first genetically engineered biologic drug (GEBD) tocilizumab, a monoclonal antibody to the interleukin (IL)
Ekaterina I. Alexeeva, Olga L. Lomakina, Tatiana M. Bzarova   +2 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

Model‐Based Meta‐Analysis With MonolixSuite: A Tutorial for Longitudinal Categorical and Continuous Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐based meta‐analysis (MBMA) informs key drug development decisions by integrating data, published or unpublished, from multiple studies. Due to these various sources of information and the use of summary‐level data (e.g., mean responses over treatment arms or percent responders), MBMA models require careful implementation.
Chloe Bracis, Amit Taneja, Yassine Kamal Lyauk, Heather Barcomb, Amparo de la Peña, Géraldine Cellière   +5 more
wiley   +1 more source

Is Canakinumab Safe During Pregnancy? New Insights from Three Cases in Slovakia

Biologics
Background and Objectives: Canakinumab, a human recombinant monoclonal antibody against interleukin-1ß (IL-1ß), is indicated for the treatment of selected autoinflammatory periodic fever syndromes and rheumatic diseases.
Branislav Slenker, Katarina Hrubiskova, Lenka Kapustova, Anna Bobcakova, Juraj Ondris, Milos Jesenak   +5 more
doaj   +1 more source

Cytokines and Inflammatory Mediators [30-39]: 30. The LPS Stimulated Production of Interleukin-10 is not Associated with -819C/T and -592C/A Promoter Polymorphisms in Healthy Indian Subjects [PDF]

, 2017
Background: Interleukin-10 is a pivotal immunoregulatory cytokine with pleiotropic effects on the immune system. IL-10 promoter polymorphisms have been associated with disease susceptibility and the ability to secrete IL-10 in vitro.
Aggarwal, Amita, Braun, J., Buckley, Christopher, Buckley, Christopher D., Church, Leigh D., Collins, David A., Dawes, Peter, Douglas, Karen, Douglas, Karen M., Evans, Hayley G., Filer, Andrew D., Filer, Andrew D., Gasparyan, Armen Y., Govindan, Jyothish, Gullick, Nicola J., Hachulla, E., Hashizume, M., Hawkins, P. N., Hildago, Ester, Howlett, Katherine, Hoyer, J., Jayaraj, David, Juarez, Maria, Judah, Sunita M., Kirkham, Bruce W., Kitas, George D., Kitas, George D., Koike, N., Kolasinski, James, Kone-Paut, I., Koutedakis, Yiannis, Kuemmerle-Deschner, J. B., Lachmann, H. J., Lawrence, Able, Leslie, K., Mattey, Derek L., Metsios, Giorgos S., Mihara, M., Naik, Sita, Nixon, Nicola, Panoulas, Vasileios F., Patel, N., Preiss, R., Price, Elizabeth J., Quilter, Annette, Rapecki, Stephen, Raza, Karim, Raza, Karim, Salmon, Mike, Scheel-Toellner, Dagmar, Scheel-Toellner, Dagmar, Schmutz, Caroline, Shukla, Skanda, Smith, J., Stavropoulos-Kalinoglou, Antonios, Stavropoulos-Kalinoglou, Antonios, Suzuki, M., Taams, Leonie S., Thomas, Andrew, Toellner, Kai-Michael, Toms, Tracey E., Widmer, A., Williamson, Lyn, Yeo, Lorraine, Yoshida, H.   +64 more
core  

Treatment of adult-onset Still's disease: a review [PDF]

, 2014
Adult-onset Still's disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. The former classification, based on the disease course, seems to be quite dated.
Gerfaud-Valentin, M., Henry, T., Jamilloux, Y., Seve, P.   +3 more
core   +3 more sources

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

Canakinumab and cardiovascular outcomes: results of the CANTOS trial

Journal of Community Hospital Internal Medicine Perspectives, 2018
IL-1 cytokines are mainly responsible for controlling a series of pro-inflammatory reactions induced in response to pathogen mediated tissue injury. Among the IL-1 cytokine family, IL-1 β results in upregulation of genes responsible for boosting immune ...
Syed Raza Shah, Zainab Abbasi, Mazia Fatima, Rohan Kumar Ochani, Waqas Shahnawaz, Muhammad Asim Khan, Syed Arbab Shah   +6 more
doaj   +1 more source

Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]

, 2017
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario, Braghetta, Paola, Bressan, Giorgio M., Carnevale, Daniela, Carnevale, Lorenzo, Carnevale, Raimondo, Casaburo, Manuel, Cifelli, Giuseppe, DA ROS, Francesco, Fardella, Stefania, Iacobucci, Roberta, Lembo, Giuseppe, Perrotta, Marialuisa, Vinciguerra, Iolanda   +13 more
core   +1 more source