Results 91 to 100 of about 11,333,085 (312)

Thioredoxin Reductase-1 as a Potential Biomarker in Fibroblast-Associated HCT116 Cancer Cell Progression and Dissemination in a Zebrafish Model

, 2022
The tumor microenvironment, especially that of fibroblasts, strongly promotes colorectal cancer (CRC) progression. Progressive cancers usually accumulate high reactive oxygen species (ROS), leading to oxidative stress.
Tharathip Muangthong, Artchaya Hassametto, Pornnapat Chusangnin, Rataya Tanomrat, Prasit Suwannalert   +4 more
core   +1 more source

Cancer-Associated Fibroblasts in Esophageal Cancer

Cellular and Molecular Gastroenterology and Hepatology
Cancer-associated fibroblasts (CAFs), a heterogenous population, can promote cancer cell proliferation, migration, invasion, immunosuppression, and therapeutic resistance in solid tumors. These effects are mediated through secretion of cytokines and growth factors, remodeling of the extracellular matrix, and providing metabolic support for cancer cells.
Karen J. Dunbar, Kwok K. Wong, Anil K. Rustgi   +2 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Supplementary Figure S1 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Figure S1 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

Integrative analysis of cancer-associated fibroblast signature in gastric cancer

Heliyon, 2023
Background: CAFs regulate the signaling of GC cells by promoting their migration, invasion, and proliferation and the function of immune cells as well as their location and migration in the TME by remodeling the extracellular matrix (ECM).
Zidan Zhao, Tsz Kin Mak, Yuntao Shi, Kuan Li, Mingyu Huo, Changhua Zhang   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Supplementary Table S1 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Table S1 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

Cancer associated fibroblasts in hematological malignancies

Oncotarget, 2014
Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts ...
Raffaghello L, Pistoia V, VACCA, Angelo, RIBATTI, Domenico   +3 more
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells

, 2011
Head and neck squamous cell carcinoma tumors (HNSCC) contain a dense fibrous stroma which is known to promote tumor growth, although the mechanism of stroma-mediated growth remains unclear.
Hartman, Yolanda E., Zhiyong Liu, Larissa Sweeny, Eben L. Rosenthal, Yolanda E. Hartman, Sweeny, Larissa, Jason M. Warram, Knowles, Joseph A., Tong Zhou, Warram, Jason M., Rosenthal, Eben L., Zhou, Tong, Liu, Zhiyong, Joseph A. Knowles   +13 more
core   +1 more source