Results 71 to 80 of about 11,333,085 (312)

CD10+GPR77+ Cancer-Associated Fibroblasts Promote Chemoresistance

, 2018
CD10 and GPR77 define a cancer-associated fibroblast (CAF) subset that sustains cancer stemness.

core   +1 more source

Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts [PDF]

BioMed Research International, 2018
Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour microenvironment and undergo an activation process associated with secretion of growth factors, cytokines, and paracrine interactions. One of the important features of solid tumours is the metabolic reprogramming that leads to changes of bioenergetics and biosynthesis ...
Avagliano, Angelica, Granato, Giuseppina, Ruocco, Maria Rosaria, Romano, Veronica, Belviso, Immacolata, Carfora, Antonia, Montagnani, Stefania, Arcucci, Alessandro   +7 more
openaire   +3 more sources

Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia

Frontiers in Molecular Biosciences
Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular matrix (ECM). In cancers, fibroblasts play an expanded role in tumor progression and dissemination, immunosuppression, and metabolic ...
Jesus Pacheco-Torres, Jesus Pacheco-Torres, Raj Kumar Sharma, Yelena Mironchik, Flonne Wildes, W. Nathaniel Brennen, Dmitri Artemov, Dmitri Artemov, Balaji Krishnamachary, Zaver M. Bhujwalla, Zaver M. Bhujwalla, Zaver M. Bhujwalla   +11 more
doaj   +1 more source

Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors

Frontiers in Molecular Biosciences, 2019
Increasing evidence indicates that the heterogeneous tumor stroma supports therapy resistance at multiple levels. Fibroblasts, particularly cancer-associated fibroblasts (CAFs) are critical components of the tumor stroma.
Alizée Steer, Nils Cordes, Nils Cordes, Nils Cordes, Nils Cordes, Nils Cordes, Verena Jendrossek, Diana Klein   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Supplementary Figure S5 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Figure S5 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

Cancer-associated fibroblasts in digestive tumors

World Journal of Gastroenterology, 2014
The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells including tumor vascular composing cells, inflammatory cells and fibroblasts.
Lei, Huang, A-Man, Xu, Sha, Liu, Wei, Liu, Tuan-Jie, Li   +4 more
openaire   +2 more sources

Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon [PDF]

Journal of Histochemistry & Cytochemistry, 2008
Periostin is a unique extracellular matrix protein, deposition of which is enhanced by mechanical stress and the tissue repair process. Its significance in normal and neoplastic colon has not been fully clarified yet. Using immunohistochemistry and immunoelectron microscopy with a highly specific monoclonal antibody, periostin ...
Yoshinao, Kikuchi, Takeshi G, Kashima, Takashi, Nishiyama, Kazuhiro, Shimazu, Yasuyuki, Morishita, Masashi, Shimazaki, Isao, Kii, Hisanaga, Horie, Hideo, Nagai, Akira, Kudo, Masashi, Fukayama   +10 more
openaire   +3 more sources

Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression

Respiratory Research, 2017
Background The influence of lung fibroblasts on lung cancer progression is not fully understood. Methods Lung fibroblasts (HFL1, MRC5, and IMR90 cells) and non-small cell lung cancer (NSCLC)-derived cell lines (A549, EBC1, and HI1017) were cultured under
Nobuhiro Kanaji, Masanao Yokohira, Yuko Nakano-Narusawa, Naoki Watanabe, Katsumi Imaida, Norimitsu Kadowaki, Shuji Bandoh   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source