Results 61 to 70 of about 11,333,085 (312)

Automated Radiosynthesis of [¹⁸F]FluoFAPI and Its Dosimetry and Single Acute Dose Toxicological Evaluation

Pharmaceuticals
Background: Cancer-associated fibroblasts have become a new target for therapy. Fibroblasts present within malignancies express the fibroblast activation protein (FAP).
Jason A. Witek, Allen F. Brooks, Sahil M. Kapila, Wade P. Winton, Jenelle R. Stauff, Peter J. H. Scott, Benjamin L. Viglianti   +6 more
doaj   +1 more source

Supplementary Figure S2 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Figure S2 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

Supplementary Figure S6 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Figure S6 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

In search of definitions: Cancer‐associated fibroblasts and their markers [PDF]

International Journal of Cancer, 2019
The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer‐associated fibroblasts (CAFs), a type of perpetually activated fibroblasts, have been implicated to have a strong tumor‐modulating effect and play a key role in areas such as drug resistance ...
Martin Nurmik, Pit Ullmann, Fabien Rodriguez, Serge Haan, Elisabeth Letellier   +4 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Supplementary Figure S3 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

, 2022
Supplementary Figure S3 from Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck ...
Sohini Roy (743212), Diana Graves (15045846), Kamran Idrees (14974134), Michael Gibson (15045858), Aleksandar Obradovic (7549517), Paula Hurley (10941824), X. Shirley Liu (14931254), Michael Korrer (15045849), Abdullah Naveed (15045855), Peng Jiang (14956410), Andrea Califano (15018354), Yu Wang (15045852), Joseph Curry (7890260), Young J. Kim (15040152), Ravindra Uppaluri (6957617), Adam Luginbuhl (9229314), Charles G. Drake (7549529), Yaomin Xu (221417)   +17 more
core   +1 more source

Cancer-associated fibroblasts in carcinogenesis

Journal of Translational Medicine
In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer. Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous underlying causes, including inflammation and fibrosis.
Shufen Zhou, Zekun Zhao, Zhaojun Wang, Hanzheng Xu, Yijie Li, Ke Xu, Wei Li, Jiahua Yang   +7 more
openaire   +3 more sources

Cancer-associated fibroblasts in hepatocellular carcinoma

World Journal of Gastroenterology, 2016
The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts are the major source of extracellular proteins during fibrogenesis, and may directly, or secreted products, contribute to carcinogenesis and tumor progression.
Norio, Kubo, Kenichiro, Araki, Hiroyuki, Kuwano, Ken, Shirabe   +3 more
openaire   +2 more sources

344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos, Florencia Madorsky Rowdo, Jessica White, Hui-Hsuan Kuo, Enrique Podaza, Laura Martin, Olivier Elemento   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source