Results 41 to 50 of about 11,333,085 (312)

Cancer-Associated Fibroblasts: Implications for Cancer Therapy [PDF]

Cancers, 2021
Tumour cells do not exist as an isolated entity. Instead, they are surrounded by and closely interact with cells of the environment they are emerged in. The tumour microenvironment (TME) is not static and several factors, including cancer cells and therapies, have been described to modulate several of its components. Fibroblasts are key elements of the
Ana Maia, Stefan Wiemann
openaire   +2 more sources

Cancer associated fibroblasts in cancer pathogenesis [PDF]

Seminars in Cell & Developmental Biology, 2010
In the past century, gradual but sustained advances in our understanding of the molecular mechanisms involved in the growth and invasive properties of cancer cells have led to better management of tumors. However, many tumors still escape regulation and progress to advanced disease. Until recently, there has not been an organized and sustained focus on
Omar E, Franco, Aubie K, Shaw, Douglas W, Strand, Simon W, Hayward   +3 more
openaire   +2 more sources

Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Improving clinical management of early stage colorectal cancers (T1CRCs) requires a better understanding of their underlying biology.
Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H.J. Danen, Vienna N.L.N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G.T. Janson, Johan J. van der Reijden, Stijn Crobach, James C.H. Hardwick, Jurjen J. Boonstra, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels   +15 more
doaj   +1 more source

Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]

, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie, Tomasovic, Ana, Stephanie Traub, Ana Tomasovic, Ana Tomasovic (189773), Ritva Tikkanen (189783), Tikkanen Ritva, Tikkanen, Ritva, Traub, Stephanie, Tomasovic Ana, Ritva Tikkanen, Stephanie Traub (189777)   +11 more
core   +2 more sources

Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma

Cellular and Molecular Gastroenterology and Hepatology, 2023
Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis. PLC is characterized by an abundant stromal reaction in which cancer-associated fibroblasts (CAFs) are one of the major stromal components.
Ying, F, Chan, MSM, Lee, TKW
openaire   +4 more sources

Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC

OncoImmunology, 2023
Cancer associated fibroblasts (CAF) are known to orchestrate multiple components of the tumor microenvironment, whereas the influence of the whole stromal-fibroblast compartment is less understood.
Stefan Koeck, Arno Amann, Johan Kern, Marit Zwierzina, Edith Lorenz, Sieghart Sopper, Heinz Zwierzina, Finn Mildner, Martina Sykora, Susanne Sprung, Hubert Hackl, Florian Augustin, Hubert T. Maier, Andreas Pircher, Georg Pall, Dominik Wolf, Gabriele Gamerith   +16 more
doaj   +1 more source

The Role of Cancer-Associated Fibroblasts in Tumor Progression [PDF]

Cancers, 2021
In the era of genomic medicine, cancer treatment has become more personalized as novel therapeutic targets and pathways are identified. Research over the past decade has shown the increasing importance of how the tumor microenvironment (TME) and the extracellular matrix (ECM), which is a major structural component of the TME, regulate oncogenic ...
Rushikesh S. Joshi, Samanvi S. Kanugula, Sweta Sudhir, Matheus P. Pereira, Saket Jain, Manish K. Aghi   +5 more
openaire   +2 more sources

Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma

BMC Gastroenterology, 2023
Background Cancer-associated fibroblasts (CAFs) have been reported to exhibit protumorigenic effects. Among the well-known CAF markers such as smooth muscle actin (SMA) and fibroblast activation protein (FAP), high expression of SMA in the peritumoral ...
Yuhei Waki, Yuji Morine, Takayuki Noma, Chie Takasu, Hiroki Teraoku, Shinichiro Yamada, Yu Saito, Tetsuya Ikemoto, Mitsuo Shimada   +8 more
doaj   +1 more source

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PET

Biomedicines, 2022
The tumor microenvironment (TME) surrounding tumor cells is a complex and highly dynamic system that promotes tumorigenesis. Cancer-associated fibroblasts (CAFs) are key elements in TME playing a pivotal role in cancer cells’ proliferation and metastatic
Laura Gilardi, Lighea Simona Airò Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Salè, Francesco Ceci   +5 more
doaj   +1 more source

Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer [PDF]

, 2022
Despite extensive research, the 5-year survival rate of pancreatic cancer (PDAC) patients remains at only 9%. Patients often show poor treatment response, due partly to a highly complex tumor microenvironment (TME).
Rebekah Crake, Crake, Rebekah, Elisabeth Letellier, Letellier, Elisabeth, Yasmine Boumahd, Akeila Bellahcène, Bellahcene, Akeila, Peulen, Olivier, Gullo, Charlotte, Peiffer, Raphaël, Raphaël Peiffer, Charlotte Gullo, Olivier Peulen, Boumahd, Yasmine   +13 more
core   +1 more source