Results 21 to 30 of about 11,333,085 (312)

Identification of the prognostic value of elevated ANGPTL4 expression in gallbladder cancer‐associated fibroblasts

Cancer Medicine, 2021
Background Cancer‐associated fibroblasts (CAFs) with different gene profiles from normal fibroblasts (NFs) have been implicated in tumor progression. Angiopoietin‐like protein 4 (ANGPTL4) has been shown to regulate tumor angiogenesis and metastasis, and ...
Fang‐Tao Wang, Xin‐Ping Li, Mu‐Su Pan, Mohamed Hassan, Wei Sun, Yue‐Zu Fan   +5 more
doaj   +1 more source

Cancer-Associated Fibroblasts as Targets for Immunotherapy [PDF]

Immunotherapy, 2012
Immunotherapy for solid tumors has shown promise in preclinical as well as early clinical studies. However, its efficacy remains limited. The hindrance to achieving objective, long-lasting therapeutic responses in solid tumors is, in part, mediated by the dynamic nature of the tumor and its complex microenvironment.
Sunitha, Kakarla, Xiao-Tong, Song, Stephen, Gottschalk   +2 more
openaire   +2 more sources

Cancer-associated fibroblasts—heroes or villains? [PDF]

British Journal of Cancer, 2019
Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, more recently, ablation, and it is now
Gieniec, K.A., Butler, L.M., Worthley, D.L., Woods, S.L.   +3 more
openaire   +3 more sources

Cancer-Associated Fibroblast Functions as a Road-Block in Cancer Therapy

, 2021
The journey of a normal resident fibroblast belonging to the tumor microenvironment (TME) from being a tumor pacifier to a tumor patron is fascinating. We introduce cancer-associated fibroblast (CAF) as a crucial component of the TME.
Pradip De, Jennifer Aske, Nandini Dey
core   +1 more source

Cancer-associated fibroblasts

Advanced drug delivery reviews, 2022
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several tumor types and play a critical role in tumor progression and drug resistance via different mechanisms such as desmoplasia, angiogenesis, immune modulation, and cancer ...
Rimal, Rahul, Desai, Prachi, Daware, Rasika, Hosseinnejad, Aisa, Prakash, Jai, Lammers, Twan, Singh, Smriti   +6 more
openaire   +1 more source

Cancer-Associated Fibroblasts: Understanding Their Heterogeneity [PDF]

Cancers, 2020
The tumor microenvironment (TME) plays a critical role in tumor progression. Among its multiple components are cancer-associated fibroblasts (CAFs) that are the main suppliers of extracellular matrix molecules and important contributors to inflammation.
Louault, Kévin, Li, Rong-Rong, DeClerck, Yves A.   +2 more
openaire   +2 more sources

Novel signatures of cancer‐associated fibroblasts [PDF]

International Journal of Cancer, 2013
Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer‐associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein list based on 759 protein products of
Bozóky, Benedek, Savchenko, Andrii, Csermely, Péter, Korcsmáros, Tamás, Dúl, Zoltán, Pontén, Fredrik, Székely, László, Klein, George   +7 more
openaire   +4 more sources

Cancer associated-fibroblast-derived exosomes in cancer progression

Molecular Cancer, 2021
To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years in particular with the advent of clinical successes achieved by targeting immune checkpoint inhibitors (ICIs).
Chao Li, Adilson Fonseca Teixeira, Hong-Jian Zhu, Peter ten Dijke   +3 more
doaj   +1 more source

TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Journal of Translational Medicine, 2023
Background Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur.
Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong, Jun Tan, Rui Li, Hui Li, Jian Li, Wenju Wang, Ruhong Li   +21 more
doaj   +1 more source

Cancer associated fibroblast: Mediators of tumorigenesis

Matrix Biology, 2020
It is well accepted that the tumor microenvironment plays a pivotal role in cancer onset, development, and progression. The majority of clinical interventions are designed to target either cancer or stroma cells. These emphases have been directed by one of two prevailing theories in the field, the Somatic Mutation Theory and the Tissue Organization ...
Jennifer Alexander, Edna Cukierman
openaire   +3 more sources