Haematologica, 2016 Sickle cell anemia is a manifestation of a single point mutation in hemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life.
Lucile Vincent +5 more
doaj +1 more source
Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]
, 2010 Peer reviewedPublisher ...
Barabas, Klaudia +9 more
core +1 more source
Actions of N-arachidonyl-glycine in a rat inflammatory pain model
Molecular Pain, 2007 Background While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects. Recently, it has been demonstrated that the arachidonic acid-amino acid conjugate, N-arachidonyl-glycine (NA-glycine)
Vaughan Christopher W +2 more
doaj +1 more source
Cannabinoid receptors in invertebrates [PDF]
Journal of Evolutionary Biology, 2006 Abstract Two cannabinoid receptors, CB1 and CB2, are expressed in mammals, birds, reptiles, and fish. The presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. We conducted a systematic review of the literature, using expanded search parameters. Evidence presented in the literature varied
J M, McPartland +4 more
openaire +2 more sources
The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]
, 2019 © 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania +5 more
core +2 more sources
The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]
, 2015 Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia +4 more
core +1 more source
The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Cannabinoids, derivatives of Cannabis sativa L., can activate the endocannabinoid system via two endogenous receptors, CB1 and CB2. This system is crucial in regulating folliculogenesis, fertility, and reproductive function.
Vida Mirzaie +6 more
doaj +1 more source
Pharmaceutics, 2021 The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine.
Leontina Elena Filipiuc +7 more
doaj +1 more source
Pharmacology Research & PerspectivesExogenous cannabinoids have long been known to promote eating. However, the underlying mechanisms have not been completely elucidated, which is critical to understanding their utility.
Magen N. Lord +5 more
doaj +1 more source
The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss [PDF]
, 2018 Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells ...
Asmita Dhukhwa +8 more
core +4 more sources