Results 71 to 80 of about 28,315 (199)

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Airway responsiveness to acetylcholine or capsaicin in immature and mature guinea pigs in vivo

Allergology International, 2000
Non-specific airway hyperresponsiveness is a characteristic feature of bronchial asthma. Airway reactivity to cholinergics may change with age during childhood.
Hirokazu Arakawa, Hiroyuki Mochizuki, Kenichi Tokuyama, Akihiro Morikawa, Jan Lötvall   +4 more
doaj   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Analytical Quality by Design‐Guided Optimisation and Validation of a Short‐Run Stability‐Indicating Reverse‐Phase Ultra‐Fast Liquid Chromatography (RP‐UFLC) Method for the Quantitation of Nonivamide

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT Nonivamide (NON), a capsaicin analogue with similar pharmacological effects, is used in pain management, yet limited information exists on its accurate quantification by reverse‐phase liquid chromatography. A cost‐effective, efficient and precise RP‐HPLC method was developed, optimised using response surface methodology (central composite ...
Phindile Mahlangu, Madan S. Poka, Pedzisai A. Makoni, Bwalya A. Witika   +3 more
wiley   +1 more source

Development of simplified method for the detection of capsaicin using high performance liquid chromatography

Journal of Chromatography Open
Peppers are widely used for their pungency, and Scoville Heat Unit (SHU) is often used to measure the pungency of the peppers caused by compounds called capsaicinoids.
Jiang Huo, J. Heinrich Lieth, Qi Zhang, Pramod Pandey   +3 more
doaj   +1 more source

Discovery of Capsazepine as a Novel MCL1 Inhibitor for Overcoming Tamoxifen Resistance in Breast Cancer Therapy

eFood, Volume 7, Issue 2, April 2026.
MCL1 in promoting tamoxifen resistance by inhibiting apoptosis. This study demonstrates that the compound CPZ, identified through virtual screening and validated by molecular docking and experiments, directly binds to MCL1. This binding restores apoptosis and inhibits tumor growth, thereby combating resistance to endocrine therapy in breast cancer ...
Shujing Liu, Jiayin Li, Chengkun Wu, Yupeng Xiao, Jing Yu, Yu Xie, Chen Lin, Chunhua Liu, Yue Wang, Junfang Qin   +9 more
wiley   +1 more source

Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats

Journal of Pain Research, 2014
Kun Zhang,1 Somayaji Ramamurthy,1 Thomas J Prihoda,2 Maxim S Eckmann1 1Department of Anesthesiology, 2Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Purpose: The current study was designed to ...
Zhang K, Ramamurthy S, Prihoda TJ, Eckmann MS   +3 more
doaj  

Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease

The Journal of Pathology, Volume 268, Issue 4, Page 493-511, April 2026.
Abstract Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better ...
Daniel W. Hart, Aik Seng Ng, Patrycja Gazińska, Robert Goldin, Purva Gopal, Nicolize O'Dell, Ahmad Zargar, Lior Pytowski, Shamir Montazid, Chiara Bardella, James E. East, Ian P. Tomlinson, Nadine Koch, Nigel C. Bennett, Shazia Irshad   +14 more
wiley   +1 more source