Results 211 to 220 of about 298,386 (364)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection. [PDF]

PLoS Pathog
Zheng J, Chen Y, Chen S, Zhou J, Xiao H, Yang F, Liu H.   +6 more
europepmc   +1 more source

The Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity [PDF]

Luke E. Berchowitz, Thomas Wood, William S. Henriques, Harrison B. Cullen, Mayra Romero, Cecilia S. Blengini, Shreya Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Alexei Chemiakine, Rishad Khondker, José V.V. Isola, Michael B. Stout, Vincenzo A. Gennarino, Binyam Mogessie, Devanshi Jain, Karen Schindler, Yousin Suh, Blake Wiedenheft   +20 more
openalex   +1 more source

The Major Structural Protein of African Swine Fever Virus, p73, Is Packaged into Large Structures, Indicative of Viral Capsid or Matrix Precursors, on the Endoplasmic Reticulum [PDF]

, 1998
Christian Cobbold, Thomas Wileman
openalex   +1 more source

Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes

Science, 2018
X. Dai, Z. H. Zhou
semanticscholar   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

<i>Atkinsonella hypoxylon</i> virus capsid structure highlights the diversity of capsid proteins among the <i>Partitiviridae</i>. [PDF]

J Gen Virol
Venturi M, Calthorpe-Byrne M, Aftret B, McNeale D, Rehm BHA, Sainsbury F.   +5 more
europepmc   +1 more source

The C-terminal 25 amino acids of the protease and its substrate ICP35 of herpes simplex virus type 1 are involved in the formation of sealed capsids [PDF]

, 1995
L Matusick-Kumar, William W. Newcomb, Jay C. Brown, P.J. McCann, Warren Hurlburt, Steven P. Weinheimer, Min Gao   +6 more
openalex   +1 more source

Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues

Cell Proliferation, EarlyView.
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li   +11 more
wiley   +1 more source

Insights into the structure and initial host attachment of the flagellotropic bacteriophage 7-7-1. [PDF]

Commun Biol
Noteborn WEM, Ouyang R, Hoeksma T, Sidi Mabrouk A, Esteves NC, Pelt DM, Scharf BE, Briegel A.   +7 more
europepmc   +1 more source