Results 101 to 110 of about 151,947 (199)
Molecular Therapy: Nucleic Acids, 2012 Adeno-associated virus (AAV)-derived vectors are promising gene delivery systems, and a number of design strategies have been pursued to improve their performance.
Justin Judd +6 more
doaj +1 more source
Protein chainmail: catenated protein in viral capsids.
Cell, 1998 The capsid shells of bacteriophage HK97 and several other phages contain polypeptides that are covalently linked into complexes so large that they do not enter polyacrylamide gels after denaturation. The enormous apparent size of these protein complexes in HK97 derives from a novel protein topology.
openaire +2 more sources
Generation of enhanced gene delivery vectors by directed evolution of adeno-associated virus [PDF]
, 2006 Despite promising advance in the development of viral vectors based on AAV for human gene therapy, several major hurdles for a more general use remain.
Endell, Jan
core
Amino acid substitutions in FMDV capsid surface proteins.
, 2019 Amino acid substitutions in FMDV capsid surface proteins.
Patrick S. Chain (163435) +9 more
core +1 more source
In Silico Studies of Medicinal Compounds Against Hepatitis C Capsid Protein from North India
, 2014 Hepatitis viral infection is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Over one million people are estimated to be persistently infected with hepatitis C virus (HCV) worldwide.
Mohammad Ai Qahtani +9 more
core +1 more source
Location of capsid proteins in relation to the BMRF1-cores.
, 2019 Location of capsid proteins in relation to the BMRF1-cores.
Tatsuya Tsurumi (196433) +4 more
core +1 more source
Functional studies on the rotavirus non-structural proteins NSP5 and NSP6 [PDF]
The rotavirus replication cycle has not been fully characterised, one vital stage of virus replication involves large cytoplasmic occlusion bodies termed viroplasms.
Rainsford, Edward
core
Genetic and Biochemical Analyses of the Flaviviridae Capsid Proteins
, 2007 The small, enveloped viruses of the family Flaviviridae are etiological agents of numerous important human and agricultural diseases including hepatitis C, yellow fever, and bovine viral diarrhea.
Murray, Catherine Lucy
core +1 more source
Proteolytic Processing ofChlorellaVirus CVK2 Capsid Proteins
, 1997 Chlorellavirus CVK2 particles contain several capsid proteins that are selectively released by treatment with 4Murea. Seven of them (Vp52, Vp45, Vp41, Vp25, Vp20.5, Vp20, and Vp16.2) have been identified based on amino acid sequences at the N-terminus ...
SONGSRI, PUTTAPORN +3 more
core +1 more source
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery
Molecular Therapy: OncologyCurrent adeno-associated virus (AAV) gene therapies are limited by a lack of tissue-specificity, leading to toxic off-target impacts and increased therapeutic costs. More target-specific AAV vectors can offer safer and less expensive therapies.
Quan Pham +7 more
doaj +1 more source