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Role of capsid proteins in parvoviruses infection [PDF]
Virology Journal, 2015 The parvoviruses are widely spread in many species and are among the smallest DNA animal viruses. The parvovirus is composed of a single strand molecule of DNA wrapped into an icosahedral capsid. In a viral infection, the massy capsid participates in the entire viral infection process, which is summarized in this review.
Anchun Cheng +4 more
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Viral capsid proteins are segregated in structural fold space.
PLoS Computational Biology, 2013 Viral capsid proteins assemble into large, symmetrical architectures that are not found in complexes formed by their cellular counterparts. Given the prevalence of the signature jelly-roll topology in viral capsid proteins, we are interested in whether ...
Shanshan Cheng, Charles L Brooks
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Self-assembly of model proteins into virus capsids [PDF]
Journal of Physics: Condensed Matter, 2017 We consider self-assembly of proteins into a virus capsid by the methods of molecular dynamics. The capsid corresponds either to SPMV or CCMV and is studied with and without the RNA molecule inside. The proteins are flexible and described by the structure-based coarse-grained model augmented by electrostatic interactions. Previous studies of the capsid
Karol Wołek, Marek Cieplak
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Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach [PDF]
Molecular Pharmaceutics, 2010 Some viral vectors are potent inducers of cellular and humoral responses; therefore, viral vectors can be used to vaccinate against cancer or infectious diseases. This report will focus on adenovirus (Ad)-based vectors. Traditional viral-vector vaccination embodies the concept that the vector uses the host-cell machinery to express antigens that are ...
Q. Matthews
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Capsid protein structure in Zika virus reveals the flavivirus assembly process
Nature Communications, 2020 The structure of flavivirus surface proteins has been elucidated, but the conformation of capsid proteins within particles is less clear. Here, the authors provide a subnanometer resolution structure of Zika virus capsid protein within the virus particle,
Ter Yong Tan +11 more
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Journal of General Virology, 1994 The positive-sense RNA genome of beet yellows closterovirus (BYV) encompasses open reading frames (ORFs) for the viral capsid protein (CP, ORF 6) and for a CP homologue (p24, ORF 5). The sequences of the ORFs 5 and 6 were inserted into an Escherichia coli expression vector, pQE-9, under the control of the bacteriophage T5 promoter.
Joseph Atabekov +5 more
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Cellular homologs of the double jelly-roll major capsid proteins clarify the origins of an ancient virus kingdom. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Viruses are the most abundant biological entities on Earth and ubiquitous parasites of cellular life forms. The general scenario for the origin of viruses involves evolution from nonviral replicators, such as plasmids and transposons, via ...
Krupovic M, Makarova KS, Koonin EV.
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Capsid proteins of two bovine enteroviruses [PDF]
Biochemical Journal, 1970 S J Martin, M D Johnston
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Viruses, 2023 Herpesviruses are enveloped and have an amorphous protein layer surrounding the capsid, which is termed the tegument. Tegument proteins perform critical functions throughout the viral life cycle.
Soumya Sucharita +2 more
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A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
mBio, 2022 Human cytomegalovirus (HCMV) is a ubiquitous pathogen causing life-threatening disease in immunocompromised individuals. Virus-specific processes such as capsid assembly and genome packaging can be exploited to design new antiviral strategies.
Eva Maria Borst +8 more
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