Results 31 to 40 of about 1,705,592 (288)

Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking

Viruses, 2014
To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment.
Eva Bilkova, Jitka Forstova, Levon Abrahamyan   +2 more
doaj   +1 more source

Neck and capsid architecture of the robust Agrobacterium phage Milano

Communications Biology, 2023
Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail remains poorly ...
Ravi R. Sonani, Nathaniel C. Esteves, Abigail A. Horton, Rebecca J. Kelly, Amanda L. Sebastian, Fengbin Wang, Mark A. B. Kreutzberger, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman   +9 more
doaj   +1 more source

Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid [PDF]

Journal of Virology, 2005
ABSTRACT The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid ...
Xuekui, Yu, Sanket, Shah, Ivo, Atanasov, Pierrette, Lo, Fenyong, Liu, William J, Britt, Z Hong, Zhou   +6 more
openaire   +2 more sources

Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs [PDF]

, 2012
Hepatitis E virus (HEV), the causative agent of hepatitis E, is primarily transmitted via the fecal-oral route through contaminated water supplies, although many sporadic cases of hepatitis E are transmitted zoonotically via direct contact with infected ...
Meng, Xiang-Jin, Sanford, Brenton J, Kenney, Scott P, Dryman, Barbara A, Córdoba, Laura, Opriessnig, Tanja   +5 more
core   +1 more source

Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]

, 2011
The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin, Sommer, Marvin, Nour Adel M., Sen Nandini, Wang, Li, Leigh Zerboni, Nandini Sen, Reichelt, Mike, Adel M. Nour, Mike Reichelt, Zerboni, Leigh, Marvin Sommer, Perrino, John, Reichelt Mike, Arvin Ann M., Arvin, Ann M., Ann M Arvin, Nour, Adel M., Baiker, Armin, John Perrino, Zerboni Leigh, Ann M. Arvin, Sommer Marvin, Adel M Nour, Perrino John, Li Wang, Armin Baiker, Sen, Nandini, Wang Li   +28 more
core   +2 more sources

Nuclear restriction of HIV-1 infection by SUN1

Scientific Reports, 2021
Overexpression of the human Sad-1-Unc-84 homology protein 2 (SUN2) blocks HIV-1 infection in a capsid-dependent manner. In agreement, we showed that overexpression of SUN1 (Sad1 and UNC-84a) also blocks HIV-1 infection in a capsid-dependent manner.
Mirjana Persaud, Anastasia Selyutina, Cindy Buffone, Silvana Opp, Daniel A. Donahue, Oliver Schwartz, Felipe Diaz-Griffero   +6 more
doaj   +1 more source

Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly [PDF]

Structure, 2009
In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this interaction is important for capsid assembly.
Bailey, Graham, Hyun, Jae, Mitra, Alok, Kingston, Richard   +3 more
openaire   +3 more sources

A novel capsid protein network allows the characteristic internal membrane structure of Marseilleviridae giant viruses

Scientific Reports, 2022
Marseilleviridae is a family of giant viruses, showing a characteristic internal membrane with extrusions underneath the icosahedral vertices. However, such large objects, with a maximum diameter of 250 nm are technically difficult to examine at sub ...
Akane Chihara, Raymond N. Burton-Smith, Naoko Kajimura, Kaoru Mitsuoka, Kenta Okamoto, Chihong Song, Kazuyoshi Murata   +6 more
doaj   +1 more source

Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach [PDF]

Molecular Pharmaceutics, 2010
Some viral vectors are potent inducers of cellular and humoral responses; therefore, viral vectors can be used to vaccinate against cancer or infectious diseases. This report will focus on adenovirus (Ad)-based vectors. Traditional viral-vector vaccination embodies the concept that the vector uses the host-cell machinery to express antigens that are ...
openaire   +2 more sources

Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors

Viruses, 2021
Understanding of the construction and function of the HIV capsid has advanced considerably in the last decade. This is due in large part to the development of more sophisticated structural techniques, particularly cryo-electron microscopy (cryoEM) and ...
Morganne Wilbourne, Peijun Zhang
doaj   +1 more source