Results 51 to 60 of about 151,947 (199)

Structure of the herpesvirus major capsid protein [PDF]

The EMBO Journal, 2003
Herpes simplex virus-1 (HSV-1) virions are large, complex enveloped particles containing a proteinaceous tegument layer connected to an icosahedral capsid. The major capsid protein, VP5 (149 kDa), makes up both types of capsomere, pentons and hexons. Limited trypsin digestion of VP5 identified a single stable 65 kDa fragment which represents a proposed
Brian R, Bowman, Matthew L, Baker, Frazer J, Rixon, Wah, Chiu, Florante A, Quiocho   +4 more
openaire   +2 more sources

Role of capsid proteins in parvoviruses infection [PDF]

Virology Journal, 2015
The parvoviruses are widely spread in many species and are among the smallest DNA animal viruses. The parvovirus is composed of a single strand molecule of DNA wrapped into an icosahedral capsid. In a viral infection, the massy capsid participates in the entire viral infection process, which is summarized in this review.
Tu, Mengyu, Liu, Fei, Chen, Shun, Wang, Mingshu, Cheng, Anchun   +4 more
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Assembly and Translocation of Papillomavirus Capsid Proteins [PDF]

Journal of Virology, 2002
ABSTRACT The major and minor capsid proteins of polyomavirus are preassembled in the cytoplasm and translocated to the nucleus only as a VP1-VP2/VP3 complex. In this study, we describe independent nuclear translocation of the L1 major protein and the L2 minor capsid protein of human papillomavirus type 33 by several approaches.
Luise, Florin, Cornelia, Sapp, Rolf E, Streeck, Martin, Sapp   +3 more
openaire   +2 more sources

Bacteriophages and their structural organisation

, 2012
Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
E.V. Orlova, Orlova, Elena
core   +1 more source

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]

, 2005
In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
Morgan, I.M., Cordano, P., Taylor, E.R., Everett, R., R. Everett, A. Okoye, M.S. Campo, P. Cordano, E.R. Taylor, Campo, M.S., I.M. Morgan, Okoye, A.   +11 more
core   +1 more source

Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]

, 2013
Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Susan Offner, Thibault, Sarah A, Deborah Jacobs-Sera, Aaron A Best, Best, AA, Welkin H Pope, Conway, JF, Daniel A. Russell (199599), Deborah Jacobs-Sera (199566), Emily L. Stowe (431712), Stukey, Joseph, Rebekah M Dedrick, Broussard, GW, Russell, Daniel A, Offner, Susan, Marie C Pizzorno, Emily L Stowe, Pamela L. Connerly (431705), Marie C. Pizzorno (431710), Kremer, Timothy A, Conway, James F, Aaron A. Best (231720), Graham F Hatfull, Gregory W. Broussard (431704), Jacobs-Sera, Deborah, Graham F. Hatfull (174881), Connerly, PL, Kremer, TA, Connerly, Pamela L, Welkin H. Pope (199562), Hatfull, GF, Stowe, EL, Pope, Welkin H, Hendrix, Roger W, Stowe, Emily L, Best, Aaron A, Sarah A. Thibault (431713), Rebekah M. Dedrick (431706), Sarah A Thibault, James F Conway, Rockenbach, Kate, Gregory W Broussard, James F. Conway (393058), Jacobs-Sera, D, Hatfull, Graham F., Joseph Stukey, Dedrick, Rebekah M, Pamela L Connerly, Roger W Hendrix, Joseph Stukey (232098), Ogiefo, AH, Amenawon H. Ogiefo (431709), Kate Rockenbach, Susan Offner (431708), Ogiefo, Amenawon H, Daniel A Russell, Dedrick, RM, Stukey, J, Timothy A Kremer, Rockenbach, K, Amenawon H Ogiefo, Kate Rockenbach (431711), Pizzorno, Marie, Hendrix, RW, Pope, WH, Russell, DA, Broussard, Gregory W, Roger W. Hendrix (199647), Rochenbach, Kate, Pizzorno, Marie C, Offner, S, Thibault, SA, Timothy A. Kremer (431707), Pizzorno, MC, Hatfull, Graham F   +74 more
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Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

eLife, 2016
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly
Yen-Li Li, Viswanathan Chandrasekaran, Stephen D Carter, Cora L Woodward, Devin E Christensen, Kelly A Dryden, Owen Pornillos, Mark Yeager, Barbie K Ganser-Pornillos, Grant J Jensen, Wesley I Sundquist   +10 more
doaj   +1 more source

Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]

PLoS ONE, 2013
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang, Ju-Tao Guo, Jim Z Wu, Guang Yang   +3 more
doaj   +1 more source

Assembly of the Hv190S Totivirus Capsid Is Independent of Posttranslational Modification of the Capsid Protein

Virology, 1998
The genome of Helminthosporium victoriae 190S totivirus (Hv190SV) consists of two large overlapping open reading frames (ORFs), encoding a capsid protein (CP) and an RNA-dependent RNA polymerase. The capsid of Hv190SV, even though encoded by a single gene, contains three closely related capsid polypeptides: p88, p83, and p78.
Soldevila, Ana I., Huang, Shao, Ghabrial, Said A.   +2 more
openaire   +2 more sources

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS

Molecular Therapy: Methods & Clinical Development, 2022
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterization ...
Anh K. Lam, Junping Zhang, Dylan Frabutt, Patrick L. Mulcrone, Lei Li, Lifan Zeng, Roland W. Herzog, Weidong Xiao   +7 more
doaj   +1 more source