Results 51 to 60 of about 1,705,592 (288)

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 153-175).Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical ...
Pineo, Catherine
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

eLife, 2016
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly
Yen-Li Li, Viswanathan Chandrasekaran, Stephen D Carter, Cora L Woodward, Devin E Christensen, Kelly A Dryden, Owen Pornillos, Mark Yeager, Barbie K Ganser-Pornillos, Grant J Jensen, Wesley I Sundquist   +10 more
doaj   +1 more source

Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]

PLoS ONE, 2013
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang, Ju-Tao Guo, Jim Z Wu, Guang Yang   +3 more
doaj   +1 more source

Trypsin is associated with the rotavirus capsid and is activated by solubilization of outer capsid proteins

Journal of General Virology, 2005
The rotavirus capsid is made up of three concentric protein layers. The outer layer, consisting of VP7 and VP4, is lost during virus entry into the host cell. Rotavirus field isolates can be adapted to high-titre growth in tissue culture by treatment with trypsin and by supplementing the culture medium with trypsin, which cleaves VP4 into two fragments,
Benureau, Yann, Huet, Jean-Claude, Charpilienne, Annie, Poncet, Didier, Cohen, Jean   +4 more
openaire   +4 more sources

Structure of the herpesvirus major capsid protein [PDF]

The EMBO Journal, 2003
Herpes simplex virus-1 (HSV-1) virions are large, complex enveloped particles containing a proteinaceous tegument layer connected to an icosahedral capsid. The major capsid protein, VP5 (149 kDa), makes up both types of capsomere, pentons and hexons. Limited trypsin digestion of VP5 identified a single stable 65 kDa fragment which represents a proposed
Brian R, Bowman, Matthew L, Baker, Frazer J, Rixon, Wah, Chiu, Florante A, Quiocho   +4 more
openaire   +2 more sources

Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]

, 2013
Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Susan Offner, Thibault, Sarah A, Deborah Jacobs-Sera, Aaron A Best, Best, AA, Welkin H Pope, Conway, JF, Daniel A. Russell (199599), Deborah Jacobs-Sera (199566), Emily L. Stowe (431712), Stukey, Joseph, Rebekah M Dedrick, Broussard, GW, Russell, Daniel A, Offner, Susan, Marie C Pizzorno, Emily L Stowe, Pamela L. Connerly (431705), Marie C. Pizzorno (431710), Kremer, Timothy A, Conway, James F, Aaron A. Best (231720), Graham F Hatfull, Gregory W. Broussard (431704), Jacobs-Sera, Deborah, Graham F. Hatfull (174881), Connerly, PL, Kremer, TA, Connerly, Pamela L, Welkin H. Pope (199562), Hatfull, GF, Stowe, EL, Pope, Welkin H, Hendrix, Roger W, Stowe, Emily L, Best, Aaron A, Sarah A. Thibault (431713), Rebekah M. Dedrick (431706), Sarah A Thibault, James F Conway, Rockenbach, Kate, Gregory W Broussard, James F. Conway (393058), Jacobs-Sera, D, Hatfull, Graham F., Joseph Stukey, Dedrick, Rebekah M, Pamela L Connerly, Roger W Hendrix, Joseph Stukey (232098), Ogiefo, AH, Amenawon H. Ogiefo (431709), Kate Rockenbach, Susan Offner (431708), Ogiefo, Amenawon H, Daniel A Russell, Dedrick, RM, Stukey, J, Timothy A Kremer, Rockenbach, K, Amenawon H Ogiefo, Kate Rockenbach (431711), Pizzorno, Marie, Hendrix, RW, Pope, WH, Russell, DA, Broussard, Gregory W, Roger W. Hendrix (199647), Rochenbach, Kate, Pizzorno, Marie C, Offner, S, Thibault, SA, Timothy A. Kremer (431707), Pizzorno, MC, Hatfull, Graham F   +74 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source