Results 41 to 50 of about 151,947 (199)
Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors
Viruses, 2021 Understanding of the construction and function of the HIV capsid has advanced considerably in the last decade. This is due in large part to the development of more sophisticated structural techniques, particularly cryo-electron microscopy (cryoEM) and ...
Morganne Wilbourne, Peijun Zhang
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Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly
Communications Biology, 2022 A 2.9 Å resolution structure of the L-BC virus provides insight into the contacts between capsid proteins and the mechanism of capsid assembly.
Danyil Grybchuk +6 more
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Production of FMDV virus-like particles by a SUMO fusion protein approach in
Journal of Biomedical Science, 2009 Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications as carriers for foreign antigens or as ...
Liang Shu-Mei +3 more
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Intrinsically-disordered N-termini in human parechovirus 1 capsid proteins bind encapsidated RNA
Scientific Reports, 2018 Human parechoviruses (HPeV) are picornaviruses with a highly-ordered RNA genome contained within icosahedrally-symmetric capsids. Ordered RNA structures have recently been shown to interact with capsid proteins VP1 and VP3 and facilitate virus assembly ...
Shabih Shakeel +5 more
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Control of Capsid Transformations during Reovirus Entry
Viruses, 2021 Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate.
Stephanie L. Gummersheimer +2 more
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The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly [PDF]
The FEBS Journal, 2009 The mature capsid of human immunodeficiency virus, HIV‐1, is formed by the assembly of copies of a capsid protein (CA). The C‐terminal domain of CA, CTD, is able to homodimerize and most of the dimerization interface is formed by a single α‐helix from each monomer.
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Diagnostic Potential of Parechovirus Capsid Proteins [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACT To study humoral and cellular immunity against human parechovirus type 1 (HPEV1), the viral capsid proteins VP0, VP1, and VP3 were expressed and purified as glutathione S -transferase (GST)-tagged recombinant proteins. The fusion proteins were used to raise antisera in rabbits.
Annu, Alho +3 more
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The role of post-translational modifications in parvovirus life cycle
Frontiers in Veterinary ScienceParvoviruses are a group of single-stranded DNA viruses that lack an envelope and are widely distributed in both vertebrates and invertebrates. When they infect a host cell, parvoviruses take over the cell’s translational machinery to support the viral ...
Peng Liu, Liqin Yang
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Capsid protein structure in Zika virus reveals the flavivirus assembly process
Nature Communications, 2020 The structure of flavivirus surface proteins has been elucidated, but the conformation of capsid proteins within particles is less clear. Here, the authors provide a subnanometer resolution structure of Zika virus capsid protein within the virus particle,
Ter Yong Tan +11 more
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Journal of General Virology, 2005 The rotavirus capsid is made up of three concentric protein layers. The outer layer, consisting of VP7 and VP4, is lost during virus entry into the host cell. Rotavirus field isolates can be adapted to high-titre growth in tissue culture by treatment with trypsin and by supplementing the culture medium with trypsin, which cleaves VP4 into two fragments,
Benureau, Yann +4 more
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