Results 71 to 80 of about 1,705,592 (288)

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein.

PLoS Pathogens, 2023
Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the ...
Lauri Ilmari Aurelius Pulkkinen, Sarah Victoria Barrass, Marie Lindgren, Hudson Pace, Anna K Överby, Maria Anastasina, Marta Bally, Richard Lundmark, Sarah Jane Butcher   +8 more
doaj   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Identification and localization of the structural proteins of anguillid herpesvirus 1

Veterinary Research, 2011
Many of the known fish herpesviruses have important aquaculture species as their natural host, and may cause serious disease and mortality. Anguillid herpesvirus 1 (AngHV-1) causes a hemorrhagic disease in European eel, Anguilla anguilla.
van Beurden Steven J, Leroy Baptiste, Wattiez Ruddy, Haenen Olga LM, Boeren Sjef, Vervoort Jacques JM, Peeters Ben PH, Rottier Peter JM, Engelsma Marc Y, Vanderplasschen Alain F   +9 more
doaj   +1 more source

An interaction between glutathione and the capsid is required for the morphogenesis of C-cluster enteroviruses. [PDF]

PLoS Pathogens, 2014
Glutathione (GSH) is the most abundant cellular thiol playing an essential role in preserving a reduced cellular environment. Cellular GSH levels can be efficiently reduced by the GSH biosynthesis inhibitor, L-buthionine sulfoximine (BSO). The aim of our
Hsin-Chieh Ma, Ying Liu, Chunling Wang, Michael Strauss, Nina Rehage, Ying-Han Chen, Nihal Altan-Bonnet, James Hogle, Eckard Wimmer, Steffen Mueller, Aniko V Paul, Ping Jiang   +11 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Evaluation of hepatitis A virus recombinant proteins for detecting anti-HAV IgM and IgG antibodies

Microbiology Spectrum
Hepatitis A virus (HAV) is a major causative agent of self-limiting liver infections. India was highly endemic for HAV in the past; children were exposed to the virus at an early age without any disease symptoms and developed lifelong immunity.
Supriya Hunderkar, Nital Ganorkar, Atul Walimbe, Kavita Lole   +3 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling

Molecular Therapy: Methods & Clinical Development
Accurate quantification and characterization of recombinant adeno-associated virus (rAAV) capsid proteins are critical for evaluating product quality and safety, ensuring batch consistency, and informing process development of their manufacture.
Theodoros Kontogiannis, Christopher McElroy, Milena Quaglia, Carole Foy, Alexandra S. Whale, Julian Braybrook, C. Mark Smales   +6 more
doaj   +1 more source

L2, the minor capsid protein of papillomavirus

Virology, 2013
The capsid protein L2 plays major roles in both papillomavirus assembly and the infectious process. While L1 forms the majority of the capsid and can self-assemble into empty virus-like particles (VLPs), L2 is a minor capsid component and lacks the capacity to form VLPs. However, L2 co-assembles with L1 into VLPs, enhancing their assembly.
Wang, Joshua W., Roden, Richard B.S.
openaire   +2 more sources