Results 71 to 80 of about 6,660,257 (317)

Papillomavirus capsid proteins mutually impact structure

Virology, 2011
We studied a panel of mutant viruses containing wild-type and chimeric capsid HPV16 and HPV18 proteins. The mutant capsid protein expression, genome amplification, and episomal maintenance were comparable with the wild-type virus. However, the chimeric viruses varied in their titers from wild-type.
Chen, Horng-Shen, Conway, Michael J., Christensen, Neil D., Alam, Samina, Meyers, Craig   +4 more
openaire   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Force steps during viral DNA packaging ? [PDF]

, 2003
Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts, Boal, Bray, Bustamante, Cerritelli, Doi, Earnshaw, Earnshaw, Freund, Goldstein, Jané Kondev, Kindt, Lo, Meyers, Odijk, Parsegian, Prashant K. Purohit, Ptashne, Purohit, Raspaud, Rau, Rice, Riemer, Rob Phillips, Rosakis, Smith, Tao, Wang, Widom, Wikoff   +29 more
core   +2 more sources

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS

Molecular Therapy: Methods & Clinical Development, 2022
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterization ...
Anh K. Lam, Junping Zhang, Dylan Frabutt, Patrick L. Mulcrone, Lei Li, Lifan Zeng, Roland W. Herzog, Weidong Xiao   +7 more
doaj   +1 more source

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]

, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan, Chan, Karen, Dai, Xinghong, Jih, Jonathan, Liu, Fenyong, Liu, Wei, Mei, Ye, Trang, Phong, Yu, Xuekui, Zhou, Z Hong   +9 more
core   +2 more sources

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

bioRxiv, 2020
HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization and mechanism of uncoating are under debate. We adapted a strategy to visualize individual reverse-transcribed HIV-1 cDNA molecules and their association with viral
Thorsten G. Müller, V. Zila, Kyra Peters, Sandra Schifferdecker, M. Stanić, Bojana Lucic, V. Laketa, M. Lusic, B. Müller, H. Kräusslich   +9 more
semanticscholar   +1 more source

Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins [PDF]

Journal of Virology, 2008
ABSTRACT Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle.
Zerina, Kratovac, Cesar A, Virgen, Frederick, Bibollet-Ruche, Beatrice H, Hahn, Paul D, Bieniasz, Theodora, Hatziioannou   +5 more
openaire   +2 more sources

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Foamy Virus Budding and Release

Viruses, 2013
Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction ...
Dirk Lindemann, Sylvia Hütter, Irena Zurnic   +2 more
doaj   +1 more source