Results 81 to 90 of about 5,586,089 (360)

Dynamical Implications of Viral Tiling Theory [PDF]

Journal of Theoretical Biology 252 (2008) 357-369, 2007
The Caspar-Klug classification of viruses whose protein shell, called viral capsid, exhibits icosahedral symmetry, has recently been extended to incorporate viruses whose capsid proteins are exclusively organised in pentamers. The approach, named `Viral Tiling Theory', is inspired by the theory of quasicrystals, where aperiodic Penrose tilings enjoy 5 ...
arxiv   +1 more source

A snapshot of HIV-1 capsid–host interactions

Current Research in Structural Biology, 2020
From cellular deposition of the HIV-1 capsid to integration of the viral genome, the capsid constitutes a primary target of a variety of host proteins that work to either promote or inhibit HIV-1 infection.
Joshua Temple, Therese N. Tripler, Qi Shen, Yong Xiong   +3 more
doaj  

Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein.

PLoS Pathogens, 2023
Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the ...
Lauri Ilmari Aurelius Pulkkinen, Sarah Victoria Barrass, Marie Lindgren, Hudson Pace, Anna K Överby, Maria Anastasina, Marta Bally, Richard Lundmark, Sarah Jane Butcher   +8 more
doaj   +1 more source

Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for Pepino mosaic virus Capsid Protein [PDF]

Molecular Plant-Microbe Interactions®, 2014
Pepino mosaic virus (PepMV) (family Alphaflexiviridae, genus Potexvirus) is a mechanically transmitted tomato pathogen that, over the last decade, has evolved from emerging to endemic worldwide. Here, two heat-shock cognate (Hsc70) isoforms were identified as part of the coat protein (CP)/Hsc70 complex in vivo, following full-length PepMV and CP ...
Matthaios M. Mathioudakis, Ioannis Livieratos, Luis Rodriguez-Moreno, Miguel A. Aranda, Raquel Navarro Sempere   +4 more
openaire   +4 more sources

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

The capsid protein of human immunodeficiency virus: interactions of HIV‐1 capsid with host protein factors [PDF]

The FEBS Journal, 2009
HIV‐1 is a retrovirus that causes AIDS in humans. The RNA genome of the virus encodes a Gag polyprotein, which is further processed into matrix, capsid and nucleocapsid proteins. These proteins play a significant role at several steps in the viral life cycle.
Anjali P. Mascarenhas, Karin Musier-Forsyth   +1 more
openaire   +3 more sources

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Evaluation of hepatitis A virus recombinant proteins for detecting anti-HAV IgM and IgG antibodies

Microbiology Spectrum
Hepatitis A virus (HAV) is a major causative agent of self-limiting liver infections. India was highly endemic for HAV in the past; children were exposed to the virus at an early age without any disease symptoms and developed lifelong immunity.
Supriya Hunderkar, Nital Ganorkar, Atul Walimbe, Kavita Lole   +3 more
doaj   +1 more source

Minor proteins, mobile arms and membrane–capsid interactions in the bacteriophage PRD1 capsid [PDF]

Nature Structural Biology, 2002
Bacteriophage PRD1 shares many structural and functional similarities with adenovirus. A major difference is the PRD1 internal membrane, which acts in concert with vertex proteins to translocate the phage genome into the host. Multiresolution models of the PRD1 capsid, together with genetic analyses, provide fine details of the molecular interactions ...
San Martín, C, Huiskonen, J, Bamford, J, Butcher, S, Fuller, S, Bamford, D, Burnett, R   +6 more
openaire   +2 more sources

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source