Results 131 to 140 of about 5,478,695 (241)

CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis [PDF]

Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR ...
Rezvan, Ali, Cha, Sophia L, Shpall, Elizabeth J, Biederstädt, Alexander, Khoury, Joseph D, Montalvo, Melisa J, Vega, Francisco, Fowlkes, Natalie W, Liu, Bin, Uprety, Nadima, Pan, Yuchen, Lin, Pei, Jain, Antrix, Roszik, Janos, Lin, Paul, Melo Garcia, Luciana, Ensley, Emily, Jiang, Xianli, Kundu, Kiran, Deyter, Gary M, Nunez Cortes, Ana K, Rezvani, Katayoun, Varadarajan, Navin, Reyes-Silva, Francia, Guo, Xingliang, Mohanty, Vakul, Li, Ping, Kaplan, Mecit, Basar, Rafet, Marin, David, Liu, Enli, Solis Soto, Luisa M, Kumar, Bijender, Li, Ye, Jiang, Xin R, Kim, Kun H, Banerjee, Pinaki P, Zhang, Chenyu, Daher, May, Shanley, Mayra, Chen, Ken, Shrestha, Rejeena, Raso, Maria G, Fathi, Mohsen, Rafei, Hind, Muniz-Feliciano, Luis, Acharya, Sunil, Acharya, Sunil;Basar, Rafet;Daher, May;Rafei, Hind;Li, Ping;Uprety, Nadima;Ensley, Emily;Shanley, Mayra;Kumar, Bijender;Banerjee, Pinaki P;Melo Garcia, Luciana;Lin, Paul;Mohanty, Vakul;Kim, Kun H;Jiang, Xianli;Pan, Yuchen;Li, Ye;Liu, Bin;Nunez Cortes, Ana K;Zhang, Chenyu;Fathi, Mohsen;Rezvan, Ali;Montalvo, Melisa J;Cha, Sophia L;Reyes-Silva, Francia;Shrestha, Rejeena;Guo, Xingliang;Kundu, Kiran;Biederstädt, Alexander;Muniz-Feliciano, Luis;Deyter, Gary M;Kaplan, Mecit;Jiang, Xin R;Liu, Enli;Jain, Antrix;Roszik, Janos;Fowlkes, Natalie W;Solis Soto, Luisa M;Raso, Maria G;Khoury, Joseph D;Lin, Pei;Vega, Francisco;Varadarajan, Navin;Chen, Ken;Marin, David;Shpall, Elizabeth J;Rezvani, Katayoun   +47 more
core   +1 more source

Optimisation of a primary human CAR‐NK cell manufacturing pipeline

Clinical & Translational Immunology
Abstract Objectives Autologous chimeric antigen receptor (CAR) T‐cell therapy of B‐cell malignancies achieves long‐term disease remission in a high fraction of patients and has triggered intense research into translating this successful approach into additional cancer types.
Pfefferle, Aline, Contet, Julian, Wong, Kahlia, Chen, Charlotte, Verhoeyen, Els, Slichter, Chloe, Schluns, Kimberly, Cursons, Joseph, Berry, Richard, Nikolic, Iva, Rautela, Jai, Huntington, Nicholas   +11 more
openaire   +3 more sources

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Engineering and targeting potential of CAR NK cells in colorectal cancer

Chinese Medical Journal
Abstract Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promises, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost ...
Muhammad Babar Khawar, Ali Afzal, Shuangshuang Dong, Yue Si, Haibo Sun, Yuanyuan Ji   +5 more
openaire   +3 more sources

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies

OncoImmunology
CAR-based cell therapies have shown clinical success in treating various cancers, with CAR T cell therapies entering the clinical route and CAR NK cell therapies being evaluated in early-stage clinical trials.
Katharina Schindler-Wnek, Anika Stahringer, Nadine Heimer, Ulrike Koehl, Stephan Fricke, Dominik Schmiedel   +5 more
doaj   +1 more source

A Novel MICB-Targeting CAR-NK Cells for the Treatment of Pancreatic Cancer

MICB-targeting CAR-NK (chimeric antigen receptor-modified natural killer cells) therapy may serve as off-the-shelf immunotherapy. We designed soluble Anti-MICB-scFv blocks tumor immune evasion targeting the MICB antigen, thereby enhancing CAR-NK ...
Jinyi Fan, Weiyang Jin, Guanghua Yang, Jingwei Wang, Mengying Wang, Jie Fang   +5 more
core   +1 more source

Data_Sheet_2_Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing.PDF

, 2019
CAR-NK cells may represent a valuable tool, complementary to CAR-T cells, in adoptive immunotherapy of leukemia and solid tumors. However, gene transfer to human NK cells is a challenging task, particularly with non-virus-based techniques.
Tiziano Ingegnere (6647330), Francesca Romana Mariotti (6647333), Andrea Pelosi (4912558), Lorenzo Moretta (247081), Franco Locatelli (130400), Francesca Besi (768381), Paola Vacca (377695), Biagio De Angelis (6647336), Nicola Tumino (650284), Claudia Cantoni (326729), Concetta Quintarelli (6627311)   +10 more
core   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source