Results 141 to 150 of about 5,478,695 (241)

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy

Journal for ImmunoTherapy of Cancer
Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with dismal outcomes, especially in relapsed/refractory settings. Chimeric antigen receptor natural killer (CAR-NK) cell therapy holds promise but is constrained by the ...
Xin Chen, Jun Wang, Lu Wang, Weiwei Chen, Xiaohong Lu, Lei Xi, Xiaohu Fan, Pengbo Ning, Sha Gong, Yingying Bao, Nan Mei, Huanming Zhang, Huaiyu Wang   +12 more
doaj   +1 more source

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

CAR-NK cells in combination therapy against cancer: A potential paradigm

Heliyon
Various preclinical and a limited number of clinical studies of CAR-NK cells have shown promising results: efficient elimination of target cells without side effects similar to CAR-T therapy. However, the homing and infiltration abilities of CAR-NK cells
Junping Li, Hong Hu, Kai Lian, Dongdong Zhang, Pengchao Hu, Zhibing He, Zhenfeng Zhang, Yong Wang   +7 more
doaj   +1 more source

Targeting HER2-Positive Solid Tumors with CAR NK Cells: CD44 Expression Is a Critical Modulator of HER2-Specific CAR NK Cell Efficacy

Cancers
Background/Objectives: Monoclonal antibody therapies for HER2-positive tumors frequently encounter resistance, requiring alternative treatment strategies. This study investigates the use of natural killer (NK) cells expressing HER2-specific chimeric antigen receptor (CAR) to address this issue.
Bence Gergely, Márk A. Vereb, István Rebenku, György Vereb, Árpád Szöőr   +4 more
openaire   +2 more sources

Aligning Transnational due Diligence: The EU Deforestation Regulation and Brazil's Fragmented Beef Governance

Global Policy, EarlyView.
ABSTRACT Transnational due diligence regulations, such as the European Union Regulation on Deforestation‐Free Products (EUDR), are reshaping sustainability governance by transforming voluntary norms into binding global rules. Yet, their effectiveness depends on how well they align with domestic governance systems and on the power asymmetries that ...
John James Loomis, Khalid Nadvi, José Antônio Puppim de Oliveira   +2 more
wiley   +1 more source

Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals

Frontiers in Immunology
BackgroundChimeric antigen receptor (CAR) engineered natural killer (NK) cells exhibit advantages such as MHC-independent recognition and strong anti-tumor functions.
Qi Zhang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yao Wang, Yanhong Liu, Xiujuan Zheng, Yunqing Lin, Yi Chen, Yiyuan Shen, Hanmeng Qi, Lijuan Liu, Yanping Zhu, Min Zhang, Dehao Huang, Fangxiao Hu, Mengyun Zhang, Mengyun Zhang, Hui Zeng, Jinyong Wang, Jinyong Wang, Tongjie Wang, Tongjie Wang   +22 more
doaj   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Nanobody-based CAR NK cells for possible immunotherapy of MICA+ tumors

PNAS Nexus
Abstract The glycoproteins MICA and MICB are upregulated on the surface of cells undergoing stress, for instance due to (viral) infection or malignant transformation. MICA/B are the ligands for the activating receptor NKG2D, found on cytotoxic immune cells like NK cells, CD8+ T cells, and γδ T cells. Upon engagement of NKG2D, these cells
Verhaar, Elisha R, van Keizerswaard, Willemijn J C, Knoflook, Anouk, Balligand, Thomas, Ploegh, Hidde L   +4 more
openaire   +3 more sources

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Data_Sheet_1_Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing.PDF

, 2019
CAR-NK cells may represent a valuable tool, complementary to CAR-T cells, in adoptive immunotherapy of leukemia and solid tumors. However, gene transfer to human NK cells is a challenging task, particularly with non-virus-based techniques.
Tiziano Ingegnere (6647330), Francesca Romana Mariotti (6647333), Andrea Pelosi (4912558), Lorenzo Moretta (247081), Franco Locatelli (130400), Francesca Besi (768381), Paola Vacca (377695), Biagio De Angelis (6647336), Nicola Tumino (650284), Claudia Cantoni (326729), Concetta Quintarelli (6627311)   +10 more
core   +1 more source