Results 41 to 50 of about 25,600 (227)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

A Multicenter Study of Risk Factors and Outcome of Hospitalized Patients with Infections Due to Carbapenem-Resistant Acinetobacter Baumannii [PDF]

, 2011
Risk factors and outcome in patients who acquire nosocomial infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) are rarely investigated.
SHENG, WANG-HUEI;LIAO, CHUN-HSIN;YANG, LAUDERDALE TSAI-LING;KO, WEN-CHIEN;CHEN, YAO-SHEN;LIU, JIEN-WEI;LAU, YEU-JUN;LIU, KE-SUN;HSU, MENG- SHIUAN;CHANG, SHAN-CHWEN, 盛望徽;廖俊星;楊采菱;柯文謙;陳垚生;劉建衛;劉有增;劉克森;許孟璇;張上淳   +1 more
core   +1 more source

Costs for carbapenem-resistant versus carbapenem-sensitive acinetobacter baumannii infections [PDF]

, 2022
The emergence and spread of Gram-negative bacteria namely Acinetobacter baumannii, is a serious public health challenge worldwide due to antibiotics resistance.
Sarassari, Rosantia, Rochmanti, Maftuchah, Kuntaman, Kuntaman, Lashari, Yasmeen, Purba, Abdul Khairul Rizki, Notobroto, Hari Basuki   +5 more
core   +2 more sources

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Genetic Relationship of Multi-Resistant Acinetobacter baumannii Isolates in Kingdom of Saudi Arabia [PDF]

, 2018
In the last two decades, there has been a remarkable rise in the instances of nosocomial infections associated with antibiotic-resistant Acinetobacter baumannii.
Reem Aljindan, Nasreldin Elhadi
core   +1 more source

Genotypic diversity among multidrug resistant Pseudomonas aeruginosa and Acinetobacter species at Mulago Hospital in Kampala, Uganda

BMC Research Notes, 2017
Background Multidrug resistant Pseudomonas aeruginosa and Acinetobacter species are common causes of nosocomial infections worldwide. Recently we reported the occurrence of carbapenem resistant Enterobacteriaceae, P.
David P. Kateete, Ritah Nakanjako, Moses Okee, Moses L. Joloba, Christine F. Najjuka   +4 more
doaj   +1 more source

Molecular characterization and antibiotic resistance of Acinetobacter baumannii in cerebrospinal fluid and blood.

PLoS ONE, 2021
The increasing prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB) caused nosocomial infections generate significant comorbidity and can cause death among patients. Current treatment options are limited.
Xiaohong Shi, Hong Wang, Xin Wang, Huaiqi Jing, Ran Duan, Shuai Qin, Dongyue Lv, Yufeng Fan, Zhenzhou Huang, Kyle Stirling, Lei Zhang, Jiazheng Wang   +11 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

The global epidemiology of carbapenem-resistant Acinetobacter baumannii

JAC-Antimicrobial Resistance
Abstract Carbapenem-resistant Acinetobacter baumannii (CRAb) is a challenging, environmentally hardy organism with a propensity to spread within hospitals and a predilection to infect critically ill, vulnerable patients. With its potential for rapid transmission, limited treatment options, and substantial mortality, CRAb is recognized as
Angelique Boutzoukas, Yohei Doi
openaire   +2 more sources

Evaluation of carriage and environmental contamination by carbapenem-resistant Acinetobacter baumannii [PDF]

Clinical Microbiology and Infection, 2016
We evaluated the sensitivity of surveillance cultures for carbapenem-resistant Acinetobacter baumannii (CRAB) in patients and in their environment. Patients with a CRAB-positive clinical culture were sampled within 7 days; the buccal mucosa and rectum were sampled using swabs, and skin was sampled using pre-moistened sterile sponges.
A, Nutman, A, Lerner, D, Schwartz, Y, Carmeli   +3 more
openaire   +2 more sources