Results 61 to 70 of about 25,429 (227)

Carbapenem-resistant Acinetobacter baumannii contamination in an intensive care unit

, 2017
INTRODUCTION: Acinetobacter baumannii is a major pathogen causing infections in intensive care units (ICUs). In this study, we aimed to evaluate the presence of A.
Sílvia Dias de Oliveira (12696310), Otávio Hallal Ferreira Raro (9123344), Carlos Alexandre Sanchez Ferreira (12696307), Stephanie Wagner Gallo (12696304)   +3 more
core   +1 more source

Penicillin Binding Protein 7/8 Is a Potential Drug Target in Carbapenem-Resistant Acinetobacter baumannii

, 2023
Limited therapeutic options dictate the need for new classes of antimicrobials active against carbapenem-resistant Acinetobacter baumannii. Presented data confirm and extend penicillin binding protein 7/8 (PBP 7/8) as a high-value target in the CR A ...
Mathur, P, Russo, TA, Davies, CJ, Adams, FG, Eijkelkamp, BA, Barnes, O, Hutson, A, Alvarado, CL, Ascari, A, Trivedi, G, Zang, M, Carlino-MacDonald, U   +11 more
core   +1 more source

Frequency of Metallo-β-Lactamase and Antimicrobial Resistance Patterns of Acinetobacter Baumannii in Carbapenem-Resistant Isolates from Intensive Care Units of the Hospitals in Isfahan City, Iran

مجله دانشکده پزشکی اصفهان, 2015
Background: Acinetobacter baumannii is a gram-negative non-fermenting cocobacill or cocci, which is mostly found in soil, different water sources, and many healthcare environments. It is intrinsically resistance to many antibiotics.
Jina Vazirzadeh, Parisa Behshood, Leila Heidari, Hasan Ghajavand   +3 more
doaj  

Spread of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clones in patients with ventilator-associated pneumonia in an adult intensive care unit at a university hospital

Brazilian Journal of Infectious Diseases, 2015
Background: In Brazil, ventilator-associated pneumonia (VAP) caused by carbapenem resistant Acinetobacter baumannii and Pseudomonas aeruginosa isolates are associated with significant mortality, morbidity and costs.
Sabrina Royer, Ana Luiza Souza Faria, Liliane Miyuki Seki, Thiago Pavoni Gomes Chagas, Paola Amaral de Campos, Deivid William da Fonseca Batistão, Marise Dutra Asensi, Paulo P. Gontijo Filho, Rosineide Marques Ribas   +8 more
doaj   +1 more source

Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.
ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith, Rehana Bagodiya, Phuong Luong, Sakshi Shinde, Christopher M. Bland, Christopher Barry, Michael G. Bartlett, Nicholas R. Fox, Trisha N. Branan   +8 more
wiley   +1 more source

Zwitterionic Penicillin‐Derived Sulfone Inhibitor for Combating β‐Lactamase‐Mediated Antibiotic Resistance

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez, Emilio Lence, Juan C. Vázquez‐Ucha, Alejandro Beceiro, Concepción González‐Bello   +4 more
wiley   +1 more source

Molecular epidemiology of Acinetobacter baumannii during COVID-19 at a hospital in northern China

Annals of Clinical Microbiology and Antimicrobials
Background The wide spread of carbapenem-resistance clones of Acinetobacter baumannii has made it a global public problem. Some studies have shown that the prevalence of Acinetobacter baumannii clones can change over time.
Xinlin Huang, Nianzhi Ning, Deyu Li, Suming Chen, Liangyan Zhang, Huan Wang, Chunmei Bao, Xiaolan Yang, Boan Li, Hui Wang   +9 more
doaj   +1 more source

Antibacterial Therapy Options for Infections Caused by Carbapenem-Resistant Acinetobacter baumannii

Антибиотики и Химиотерапия
The review presents current treatment regimens for infections associated with carbapenem-resistant Acinetobacter baumannii, which are leading nosocomial pathogens exhibiting multidrug resistance to available antibacterial drugs. To date, widely used beta-
A. R. Goncharova, V. V. Gostev, N. E. Goncharov, O. S. Kalinogorskaya, N. S. Gladyshev   +4 more
doaj   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology
Patients with severe carbapenem-resistant Acinetobacter baumannii (CRAB) infections currently face significant treatment challenges. When patients display signs of infection and the clinical suspicion of CRAB infections is high, appropriate treatment should be immediately provided. However, current treatment plans and clinical data for CRAB are limited.
Siqin Zhang, Lingfang Di, Yan Qi, Xiang Qian, Siwei Wang   +4 more
openaire   +3 more sources