Results 91 to 100 of about 11,802 (200)

Phenotypic characterisation and prevalence of carbapenem-resistant Enterobacterales in a tertiary care centre in Bihar India. [PDF]

Sci Rep
Carbapenem-resistant Enterobacterales (CRE) infections pose a global health threat due to limited treatment options. This study aimed to determine the prevalence, phenotypic characteristics, and distribution of CRE classes in Bihar, India.
DebBarma P, Kokkayil P, Sarfraz A, Pati BK, Thakuria B.   +4 more
europepmc   +2 more sources

Interplay Between Virulence Genes, Antimicrobial Resistance Profiles, and Biofilm Formation in Klebsiella pneumoniae Causing Urinary Tract Infections in North Lebanon

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
– Figure design (single panel) Central icon: K. pneumoniae cell Left panel – Virulence genes (icons): Adhesion: fimH, mrkD → strong biofilm Capsule/regulation: magA, rmpA Siderophores: entB, iucA → iron uptake Right panel – Outcomes: Biofilm strength (weak → strong gradient) Antibiotic resistance (ESBL, MDR) Bottom split: Hospital‐acquired → strong ...
Mazen Zaylaa, Rayan Farha, Jana Taleb, Amal Saad, Omar El Gharbawy, Ricardo Sarraf, Ibtihal Kassam, Chadi Hamdach, Nisrine Bissar   +8 more
wiley   +1 more source

Real-world use of eravacycline for the treatment of mono- and polymicrobial infections involving Enterobacterales

Microbiology Spectrum
Bacterial species in the Enterobacterales order are commonly encountered causative organisms in hospital-acquired infections. Furthermore, the incidence of carbapenem-resistant Enterobacterales (CRE) is a growing threat worldwide. Eravacycline (ERV) is a
Sean R. Van Helden, Ashlan J. Kunz Coyne, Sara Alosaimy, Abdalhamid M. Lagnf, Kyle C. Molina, S. Lena Kang-Birken, Kimberly C. Claeys, Mark Biagi, Justin Andrade, Alaina DeKerlegand, Melanie Rae Schrack, Tristan Gore, Madeline A. King, Benjamin M. Pullinger, Serina Tart, Athena L. V. Hobbs, Jazmin Agee, Nicholson B. Perkins, Michael P. Veve, Reese Cosimi, Shelbye R. Herbin, Bruce M. Jones, Amy K. Feehan Curley, Chloe Judd, Mohammed Al Musawa, Michael J. Rybak   +25 more
doaj   +1 more source

The Role of Neonatal Ward Environment as a Reservoir for the Dissemination of Multidrug‐Resistant Klebsiella pneumoniae in Algeria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Whole‐genome sequencing of multidrug‐resistant Klebsiella pneumoniae from a neonatal ward environment in Chlef revealed persistent resistance genes and the clonal spread of high‐risk ST13. These findings highlight the hospital environment as a potential reservoir for transmission of resistant K. pneumoniae.
Meriem Derkaoui, Martin Alexander Fischer, Mohammed Sebaihia, Rachida Namoune, Fatiha Bouheudjeur, Meryem Beloukarif, Bakhta Madaoui, Bruno Silvester Lopes   +7 more
wiley   +1 more source

Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.
ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith, Rehana Bagodiya, Phuong Luong, Sakshi Shinde, Christopher M. Bland, Christopher Barry, Michael G. Bartlett, Nicholas R. Fox, Trisha N. Branan   +8 more
wiley   +1 more source

Global Escalation in Carbapenem-Resistant Enterobacterales and Carbapenem-Resistant Acinetobacter baumannii Infections

Biomedical and Biotechnology Research Journal (BBRJ), 2023
Rise in carbapenem-resistant Gram-negative bacterial infections, especially among immunocompromised patients in healthcare settings is an imminent threat as they are difficult to treat and result in a prolonged length of hospital stay, frequent treatment failures, increased economic burden on the patient and the nation, and a ...
openaire   +2 more sources

Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key evidence gaps

The Lancet Regional Health. Western Pacific
Summary: Gram-negative bacterial infections remain a major cause of morbidity and mortality in children and neonates globally, compounded by the rise of antimicrobial resistance. Barriers to paediatric antibiotic licencing lead to reduced availability of
Daniel K. Yeoh, Alison Boast, Sophie CH. Wen, Phoebe CM. Williams, Lesley Voss, Brett Ritchie, Mona Mostaghim, Flora Lutui, Alice Lei, Tony Lai, Adam D. Irwin, Kiera Harwood, Thomas Ewin, Celia Cooper, Emma Best, Sarah Bannister, Amanda Gwee, Sean Beggs, Asha Bowen, Jeremy Carr, Te Yu Hung, Ulrik Lorenzen, Brendan McMullan, Bradley Rockliff, Thomas Snelling, Tony Walls, Heather Weerdenburg, Amanda Wilkins   +27 more
doaj   +1 more source

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 11, Page 1487-1494, June 2026.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Risk Factors for Carbapenem-Resistant Enterobacterales Clinical Treatment Failure

, 2023
The Centers for Disease Control and Prevention (CDC) categorized carbapenem-resistant Enterobacterales (CRE) infections as an urgent health care threat requiring public attention and research.
Kunz Coyne, Ashlan J, Mannino, Andrew, Veve, Michael P, Alosaimy, Sara, Caniff, Kaylee E, Rebold, Nicholas, Rybak, Michael J, El Ghali, Amer, Dierker, Michelle, Witucki, Paige, Holger, Dana J, Lucas, Kristen, Lagnf, Abdalhamid M   +12 more
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