Results 131 to 140 of about 24,917 (198)
APMIS, Volume 134, Issue 9, September 2026.ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz +7 more
wiley +1 more source
Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery
, 2019 Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics. However, the molecular basis for their unique broad-spectrum substrate profile is poorly understood, particularly for ...
Orville A. Pemberton +17 more
core +1 more source
Journal of Infection in Developing CountriesIntroduction: Klebsiella pneumoniae is an encapsulated Gram-negative bacterium that is responsible for numerous infections in healthcare facilities worldwide and is frequently isolated. The World Health Organization has listed K.
Boukaré Kaboré +8 more
doaj +1 more source
[KPC: Klebsiella pneumoniae carbapenemase, main carbapenemase in Enterobacteriaceae].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2018 The dissemination of carbapenemase-producing Enterobacteriaceae is currently considered a serious clinical problem due to the failure in the treatment of infections produced by them. Among the carbapenemases, the enzyme KPC has spread worldwide and has been identified in the main enterobacterial species related with healthcareassociated infections ...
Alejandra, Vera-Leiva +7 more
openaire +1 more source
Zoonoses and Public Health, Volume 73, Issue 6, Page 516-527, September 2026.ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias +5 more
wiley +1 more source
Methodological Evaluation of Carbapenemase Detection by Different Methods
Polish Journal of MicrobiologyThe global proliferation of carbapenemase-producing bacteria (CPB) has garnered significant attention worldwide. Early diagnosis of CPB and accurate identification of carbapenemases are crucial for preventing the spread of CPB and ensuring targeted ...
Gao Nana +5 more
doaj +1 more source
Вестник анестезиологии и реаниматологииThe objective was to study the risk factors, outcomes of infections caused by colistin-resistant K. pneumonia (CRKP) and to evaluate the sensitivity of these microorganisms to antibacterial agents to determine the most adequate antibiotic therapy ...
I. N. Sychev +8 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 16, 27 August 2026.Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa +6 more
wiley +1 more source
Эпидемиология и вакцинопрофилактикаRelevance. In the last decade, there has been an increase in the isolation of antibiotic-resistant microorganisms in community settings. Colonization and asymptomatic carriage of extended-spectrum beta-lactamase and carbapenemase producers can be a ...
O. G. Ni +7 more
doaj +1 more source
Инфекция и иммунитет, 2018 Susceptibility to 16 antimicrobial agents in 421 Klebsiella pneumoniae strains, isolated in a multidisciplinary medical centre from patients with nosocomial infections in 2015, was tested.
N. S. Kozlova +2 more
doaj +1 more source