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The emerging NDM carbapenemases [PDF]
Trends in Microbiology, 2011 Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice +3 more
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Current methods for the identification of carbapenemases
Journal of Chemotherapy, 2016Detection of carbapenemases in clinical microbiology labs is a challenging issue. Comparison of the results of susceptibility testing with the breakpoint values of carbapenems is the first step in the screening of carbapenemase producers. To date, screening of carbapenemase-producing (CP) bacteria has been mostly performed by a selective medium ...
Kafil Hs +2 more
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Emerging carbapenemases: a global perspective
International Journal of Antimicrobial Agents, 2010The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants.
Timothy R Walsh
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Update on the epidemiology of carbapenemases in Latin America and the Caribbean [PDF]
Expert Review of Anti-Infective Therapy, 2021 Disponible en: https://www.tandfonline.com/doi/abs/10.1080/14787210.2020.1813023Abstract Introduction: Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems.
Tobias Manuel Appel, Ana C Gales
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Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe [PDF]
Clinical Microbiology and Infection, 2012 Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate.
Murat áková +2 more
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Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance [PDF]
International Journal of Molecular Sciences, 2015 Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative ...
Asad Mustafa Karim +2 more
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AZETIDINIMINES AS CARBAPENEMASES INHIBITORS [PDF]
, 2017 The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates
DODD ROBERT +4 more
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Reviews in Medical Microbiology, 2017
Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali +4 more
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Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali +4 more
openaire +1 more source