Results 181 to 190 of about 20,063 (216)

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

International Journal of Molecular Sciences, 2015
Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative ...
Asad Mustafa Karim, Jeong Ho Jeon, Sang Hee Lee   +2 more
exaly   +2 more sources

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Current methods for the identification of carbapenemases

Journal of Chemotherapy, 2016
Detection of carbapenemases in clinical microbiology labs is a challenging issue. Comparison of the results of susceptibility testing with the breakpoint values of carbapenems is the first step in the screening of carbapenemase producers. To date, screening of carbapenemase-producing (CP) bacteria has been mostly performed by a selective medium ...
Hossein Samadi Kafil, Mohammad Asgharzadeh, Mehdi Yousefi   +2 more
exaly   +3 more sources

Emerging carbapenemases: a global perspective

International Journal of Antimicrobial Agents, 2010
The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants.
Timothy R. Walsh
exaly   +3 more sources

Carbapenemase inhibitors

Reviews in Medical Microbiology, 2017
Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali, Abed Zahedi Bialvaei, Mohammad Aghazadeh, Mohammad Asgharzadeh, Hossein Samadi Kafil   +4 more
openaire   +1 more source

Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe

Clinical Microbiology and Infection, 2012
Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate.
Ørjan Samuelsen, Murat Akova, Rafael Cantón   +2 more
exaly   +2 more sources

Rapid LC–MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales

European Journal of Clinical Microbiology & Infectious Diseases, 2022
Klebsiella pneumoniae carbapenemase (KPC)-2, metallo-beta-lactamases (MBL), and oxacillinase (OXA)-48-like carbapenemases are considered the most important carbapenemases. In vitro studies have demonstrated that the carbapenemase activity of KPC-2 and MBL can be inhibited by 3-aminophenylboronic acid and ethylenediaminetetraacetic acid (EDTA ...
Gen Li, Zhihan Ye, Wenyan Zhang, Nianzhen Chen, Yangqin Ye, Yuchao Wang, Fei Wu, Keli Wang, Lieying Fan   +8 more
openaire   +2 more sources

Carbapenemases: a worldwide threat

Expert Review of Anti-infective Therapy, 2013
β-lactam antibiotics remain one of our workhorse classes for serious infection due to their usually broad activity and attractive safety profile.
openaire   +2 more sources

Development and evaluation of the method for detecting metallo-carbapenemases among carbapenemase-producing Enterobacteriaceae

Journal of Microbiological Methods, 2019
A simple EDTA synergistic carbapenem inactivation method (esCIM) based on the simplified carbapenem inactivation method (sCIM) and EDTA synergistic carbapenem inactivation test (eCIM) detected the levels of metallo-β-lactamases (MBLs) carbapenemase.
Quanfeng, Liao, Yun, Xie, Chengcheng, Wang, Zhiyong, Zong, Siying, Wu, Ya, Liu, Weili, Zhang, Yi, Xie, Yuling, Xiao, Mei, Kang   +9 more
openaire   +2 more sources

Detection systems for carbapenemase gene identification should include the SME serine carbapenemase

International Journal of Antimicrobial Agents, 2013
Carbapenemase detection has become a major problem in hospitals that encounter outbreaks of infections caused by carbapenem-resistant Gram-negative bacteria. Rapid detection systems have been reported using multiplex PCR analyses and DNA microarray assays.
Karen, Bush, Megan, Pannell, John L, Lock, Anne Marie, Queenan, James H, Jorgensen, Ryan M, Lee, James S, Lewis, Deidre, Jarrett   +7 more
openaire   +2 more sources

Carbapenemases: a problem in waiting?

Current Opinion in Microbiology, 2000
Carbapenems are stable to most prevalent beta-lactamases, and chromosomal carbapenemases are restricted to Stenotrophomonas maltophilia, to a few Bacteroides fragilis, and to rare pathogens. Nevertheless, an acquired metallo-beta-lactamase called IMP-1 is beginning to emerge in Pseudomonas aeruginosa and Enterobacteriaceae isolates in Japan, and has ...
D M, Livermore, N, Woodford
openaire   +2 more sources