Results 11 to 20 of about 43,420 (302)
Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy [PDF]
Frontiers in Microbiology, 2019 Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in the past few years, posing great challenges to human health. The plasmid-mediated horizontal transmission of carbapenem-resistance genes is the main cause of the surge ...
Xiaoyan Cui, Haifang Zhang, Hong Du
semanticscholar +5 more sources
Carbapenemase-producing organisms: a global scourge [PDF]
Clinical Infectious Diseases, 2018 The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern.
Bonomo, Robert A +6 more
core +5 more sources
Carbapenemases: the Versatile β-Lactamases [PDF]
Clinical Microbiology Reviews, 2007 SUMMARYCarbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these β-lactamases may cause serious infections in which the carbapenemase activity renders many β-lactams ineffective.
A. Queenan, K. Bush
semanticscholar +4 more sources
Rapid detection of carbapenemase-producing Enterobacteriaceae. [PDF]
Emerging Infectious Diseases, 2012 To rapidly identify carbapenemase producers in Enterobacteriaceae, we developed the Carba NP test. The test uses isolated bacterial colonies and is based on in vitro hydrolysis of a carbapenem, imipenem.
Dortet, L, Nordmann, P, Poirel, L
core +7 more sources
To Be or Not to Be an OXA-48 Carbapenemase [PDF]
Microorganisms, 2022 Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems and penicillins with very weak or almost no activity against expanded-spectrum cephalosporins, some ...
Laura Dabos +5 more
openaire +3 more sources
Evaluation of Xpert Carba-R for detecting carbapenemase-producing organisms in South Africa
African Journal of Laboratory Medicine, 2023 This study evaluated the performance of the Xpert Carba-R assay for detecting the five common carbapenemases in carbapenemase-producing organisms in Johannesburg, South Africa between April 2021 and September 2021.
Sanelisiwe T. Duze +5 more
doaj +1 more source
European Journal of Clinical Microbiology and Infectious Diseases, 2022 To evaluate the prevalence of multi-carbapenemase-producing Enterobacterales (EB) and the activity of cefiderocol (CFDC), meropenem-vaborbactam (MEV), ceftazidime-avibactam (CZA), and combinations of CZA plus aztreonam (ATM), MEV plus ATM and CFDC plus ...
G. Bianco +6 more
semanticscholar +1 more source
Антибиотики и Химиотерапия, 2022 The rapid spread of gram-negative bacteria resistance to carbapenems due to the production of carbapenemases requires new treatment options. The activity of carbapenem antibiotic biapenem, recently registered in Russia, against producers of various ...
V. A. Ageevets +9 more
doaj +1 more source
BMC Microbiology, 2022 Background Proteus mirabilis is an opportunistic pathogen, causing a variety of community-acquired and nosocomial illnesses. It poses a potential threat to patients via the production of β-lactamases, which decrease the efficacy of antimicrobial ...
Mona I. Shaaban +2 more
semanticscholar +1 more source
Journal of Antimicrobial Chemotherapy, 2007 Carbapenems, such as imipenem and meropenem, are most often used to treat infections caused by enterobacteria that produce extended-spectrum beta-lactamases, and the emergence of enzymes capable of inactivating carbapenems would therefore limit the options for treatment.
Walther-Rasmussen, J., Høiby, N.
openaire +3 more sources