Results 31 to 40 of about 19,967 (214)

Novel Rapid Test for Detecting Carbapenemase [PDF]

Emerging Infectious Diseases, 2020
We developed a carbapenemase test based on the ability of imipenem to inhibit noncarbapenemase β-lactamases. The test uses bacterial isolates with a fluorescent β-lactamase substrate, producing objective results with 100% sensitivity and specificity in 10 minutes. The assay is inexpensive and consists of only 1 mixing step.
Yanfang Feng, Akilan Palanisami, Jerrin Kuriakose, Michael Pigula, Shoaib Ashraf, Tayyaba Hasan   +5 more
openaire   +3 more sources

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionInfections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents.
Eduardo Rodríguez-Noriega, Elvira Garza-González, Paola Bocanegra-Ibarias, Beatriz Alejandra Paz-Velarde, Sergio Esparza-Ahumada, Sergio Esparza-Ahumada, Esteban González-Díaz, Esteban González-Díaz, Héctor R. Pérez-Gómez, Rodrigo Escobedo-Sánchez, Gerardo León-Garnica, Gerardo León-Garnica, Rayo Morfín-Otero   +12 more
doaj   +1 more source

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, EarlyView.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source

Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study

Frontiers in Microbiology, 2022
Among Enterobacterales, Klebsiella pneumoniae (Kp) is one of the major opportunistic pathogens causing hospital-acquired infections. The most problematic phenomenon linked to Kp is related to the dissemination of multi-drug resistant (MDR) clones ...
Fabio Arena, Fabio Arena, Fabio Arena, Giulia Menchinelli, Vincenzo Di Pilato, Riccardo Torelli, Alberto Antonelli, Alberto Antonelli, Lucia Henrici De Angelis, Marco Coppi, Marco Coppi, Maurizio Sanguinetti, Maurizio Sanguinetti, Gian Maria Rossolini, Gian Maria Rossolini, Gian Maria Rossolini   +15 more
doaj   +1 more source

Carbapenemase-producingEnterobacteriaceae, U.S. Rivers

Emerging Infectious Diseases, 2005
Our study was initiated by previous isolation of 30 imipenem-resistant, gram-negative rods from 7 of 16 U.S. rivers sampled from 1999 to 2001. Imipenem hydrolysis was detected in 22 of those isolates identified as Enterobacter asburiae. Random amplified polymorphism DNA analysis showed that these E. asburiae isolates were genetically indistinguishable.
Cécile Aubron, Laurent Poirel, Ronald J Ash, Patrice Nordmann   +3 more
openaire   +3 more sources

Point‐of‐Care Testing by Multiplex‐PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation—Results of a Prospective Study

Transplant Infectious Disease, EarlyView.
Use of POCtmPCR with noninvasive samples (NPS and sputum) in LTx recipients with viral LRTI are a viable alternative to invasive BAL sampling, ABSTRACT Background Respiratory tract infections (RTIs) are a leading cause of morbidity and mortality following lung transplantation (LTx).
Susanne Simon, Merle Sophie Kaiser, Marcus Bachmann, Gérard Krause, Jens Gottlieb   +4 more
wiley   +1 more source

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

Antibiotics, 2020
The Enterobacteriales order consists of seven families including Enterobacteriaceae, Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and Budviciaceae and 60 genera encompassing over 250 species.
Gurleen Taggar, Muhammad Attiq Rehman, Patrick Boerlin, Moussa Sory Diarra   +3 more
doaj   +1 more source

Confronting Carbapenemase-Producing Klebsiella Pneumoniae

Future Microbiology, 2013
The ongoing spread of carbapenemase-producing (CP) multidrug-resistant enterobacteria, primarily Klebsiella pneumoniae, has undoubtedly caused a public health crisis of unprecedented dimensions. The scientific community has been struggling with these highly problematic nosocomial pathogens for more than a decade.
Markogiannakis, A., Tzouvelekis, L.S., Psichogiou, M., Petinaki, E., Daikos, G.L.   +4 more
openaire   +3 more sources

Molecular Respiratory Pathogen Panels in Lung Transplantation

Transplant Infectious Disease, EarlyView.
ABSTRACT Molecular respiratory pathogen panels are an innovative tool for the rapid detection of respiratory pathogens and antimicrobial resistance genes, offering the potential to improve diagnostic accuracy and guide timely antimicrobial therapy.
Andrea Lombardi
wiley   +1 more source