Results 181 to 190 of about 13,653 (252)
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Microwave‐Assisted Synthesis of Tetrahydro‐β‐carbolines and β‐Carbolines
European Journal of Organic Chemistry, 2014AbstractA microwave‐mediated Pictet–Spengler procedure utilizing 1,2‐dichloroethane (DCE) and trifluoroacetic acid (TFA) was developed to provide tetrahydro‐β‐carboline salts in high yields. Reactions are complete in 20 minutes or less and the product precipitates from solution in high yields and purity, negating the need for liquid–liquid extraction ...
Scott Eagon, Marc O. Anderson
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A review of the synthesis of α-carbolines
European Journal of Medicinal Chemistry, 2015Since the first reported synthesis of an α-carboline almost a century ago, there has been a steady interest in the development of strategies towards this unique heterocyclic motif. This interest can mainly be attributed to a range of biological activity displayed by the α-carboline natural products including cytotoxicity, anticancer properties or CNS ...
Andrew D. Wadsworth +2 more
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The photocyclisation of anilino-pyridines to carbolines
Journal of the Chemical Society C: Organic, 1968Irradiation of some anilino-pyridines has been shown to yield carbolines. A new heterocyclic system, 9H-pyrrolo[2,3-b : 5,4-b′]dipyridine, is described.
V M, Clark, A, Cox, E J, Herbert
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1982
1. The inhibition of specific 3H-flunitrazepam binding to rat cortical membrane preparations (benzodiazepine receptors) by a series of amide derivatives of beta-carboline and tetrahydro-beta-carboline related to the ethyl ester of beta-carboline 3-carboxylate (beta-CCE) was measured. 2.
R A, Locock +4 more
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1. The inhibition of specific 3H-flunitrazepam binding to rat cortical membrane preparations (benzodiazepine receptors) by a series of amide derivatives of beta-carboline and tetrahydro-beta-carboline related to the ethyl ester of beta-carboline 3-carboxylate (beta-CCE) was measured. 2.
R A, Locock +4 more
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Journal of Organic Chemistry, 2018
Brønsted acid-mediated, transition-metal-free reaction of propargyl alcohols with sulfonamido-indoles/-indolines under mild conditions affords highly substituted δ- or α-carbolines in good to excellent yields.
Karuppu Selvaraj, K. C. Kumara Swamy
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Brønsted acid-mediated, transition-metal-free reaction of propargyl alcohols with sulfonamido-indoles/-indolines under mild conditions affords highly substituted δ- or α-carbolines in good to excellent yields.
Karuppu Selvaraj, K. C. Kumara Swamy
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Tetrahedron Letters, 2018
Temperature controlled chemoselective dehydrogenation and aromatization of tetrahydro-β-carbolines, using molecular I2 and H2O2, in DMSO solvent affords a practical access to a series of corresponding 3,4-dihydro-β-carbolines and β-carbolines ...
S. Gaikwad +2 more
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Temperature controlled chemoselective dehydrogenation and aromatization of tetrahydro-β-carbolines, using molecular I2 and H2O2, in DMSO solvent affords a practical access to a series of corresponding 3,4-dihydro-β-carbolines and β-carbolines ...
S. Gaikwad +2 more
semanticscholar +1 more source
Analysis of the bioactive alkaloids tetrahydro-β-carboline and β-carboline in food
Journal of Chromatography A, 2000Simple tetrahydro-beta-carbolines (THbetaCs) and beta-carbolines (betaCs) are naturally occurring alkaloids in foods and food processing. This paper reviews the methods employed for their analysis. Procedures for THbetaC and betaC isolation and clean-up to remove interfering compounds are carried out by liquid-liquid extraction, and/or better solid ...
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TRYPTAMINES, CARBOLINES, AND RELATED COMPOUNDS: PART VIII. δ-CARBOLINE
Canadian Journal of Chemistry, 1960The first unambiguous synthesis of δ-carboline has been achieved starting with 3-amino-2-phenylpyridine. This was converted to the azide which was thermally cyclized to δ-carboline. The carboline gave a py-N-methiodide which was converted to the anhydronium base. The pKa of the anhydronium base was determined and its significance is discussed.
R. A. Abramovitch +2 more
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2000
Abstract Interaction of potential environmental neurotoxins with genetic susceptibility is considered important in the etiology of idiopathic PD (43,64,101). N-Methylated /3Cs and IQs, which contain pyridinium moieties like MPP+ and can in hibit mitochondrial respiration, are reasonable candidatesages, but their pyrolytic formation ...
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Abstract Interaction of potential environmental neurotoxins with genetic susceptibility is considered important in the etiology of idiopathic PD (43,64,101). N-Methylated /3Cs and IQs, which contain pyridinium moieties like MPP+ and can in hibit mitochondrial respiration, are reasonable candidatesages, but their pyrolytic formation ...
openaire +1 more source