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Carbon Ion Radiotherapy

Carbon Ion Radiotherapy
The use of charged particles in medical radiotherapy(RT)was first suggested in 1946 by physicist Robert Wilson, a formerstudent of Ernest Lawrence, Nobel Prize winner for developing the cyclotron at the University of California, Berkeley. Following his perticipation in the Manhattan project and having been disap-pointed at the use of atomic weapons ...
openaire  

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Advances in radiotherapy for mouth neoplasms: emerging technologies and future perspectives

Discover Oncology
Oral cancer is a common malignant tumor of the head and neck region, significantly impacting human health and quality of life. Radiotherapy has become an essential component of treatment, often used in combination with surgery and/or chemotherapy ...
Xuhong Liu, Zhuoya Zhang, Xinyu Deng, Zekun Lang, Jianrong Wang   +4 more
doaj   +1 more source

Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2092-2105, April 2026.
ABSTRACT Purpose To evaluate quantitative susceptibility mapping (QSM) beyond the brain through realistic simulations and to explore preliminary evidence that may be indicative of hypoxia in skull base chordomas (SBC). Methods Each step of the QSM pipeline was optimized within an in silico framework consisting of (i) phase unwrapping, (ii) background ...
P. Fenech, L. Morelli, G. Parrella, S. Imparato, A. Iannalfi, S. Lillo, E. Orlandi, G. Baroni, C. Paganelli   +8 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Prospective Registry and Meta‐Analysis of Particle Therapy for Hepatocellular Carcinoma: Clinical Outcomes and Real‐World Impact

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background and Aims This study aimed to evaluate the clinical efficacy of particle therapy for hepatocellular carcinoma (HCC) by integrating a prospective registry and a systematic meta‐analysis. Our findings also reflect the real‐world impact of this evidence, which contributed to the national health insurance approval of particle therapy for
Masashi Mizumoto, Kei Shibuya, Kazuki Terashima, Hiromitsu Iwata, Takashi Saito, Shingo Toyama, Takashi Ogino, Masao Murakami, Tatsuya Ohno, Yoshitaka Sato, Tetsuo Akimoto, Hiroyuki Katoh, Masaru Wakatsuki, Takahiro Waki, Norio Katoh, Fuki Koizumi, Masayuki Araya, Tsuyoshi Onoe, Masaru Takagi, Tomoaki Okimoto, Hiroyuki Ogino, Haruko Numajiri, Yoshiyuki Shioyama, Takayuki Hashimoto, Hisateru Ohba, Shoji Kubo, Kiyoshi Hasegawa, Kazushi Maruo, Hidefumi Aoyama, Hideyuki Sakurai   +29 more
wiley   +1 more source

Consensus recommendations in the management of jaw (gnathic) osteosarcoma

Cancer, Volume 132, Issue 5, 1 March 2026.
Abstract Gnathic osteosarcoma (OS), which includes mandibular and maxillary jaw OSs, account for 6%–9% of OS. Single‐institutional and multi‐institutional retrospective studies, as well as population‐level databases, suggest that clinical differences exist among gnathic OS and OS of other sides, including other craniofacial OS.
Matthew S. Dietz, Lara E. Davis, Pinki K. Prasad, Shauna R. Campbell, John D. Reith, Mallery R. Olsen, Scott E. Kilpatrick, Jamie A. Ku, Natalie L. Silver, Earl P. Park, Elisa Tirtei, Cristina Meazza, Erin S. Murphy, Nicole C. Mallory, Emanuela Palmerini, Leo Kager, Marinka L. F. Hol, Roelof van Ewijk, Joseph Lopez, Leighton A. Elliott, Dale R. Shepard, Ajay Gupta, Matteo M. Trucco   +22 more
wiley   +1 more source

Overview of carbon ion radiotherapy

Overview of carbon ion radiotherapy
In cancer radiotherapy (RT), ion beams such as proton and carbon ion beams have unique characteristics of improved dose distributions, enabling a delivery of sufficient dose to the target volume while minimizing the dose in the surrounding normal tissues. In addition, carbon ions being heavier than protons provide a higher biological effectiveness with
openaire   +1 more source

Editorial: 3rd International Workshop on Microdosimetry for Particle Therapy: Bridging Physics and Biology

Precision Radiation Oncology, EarlyView.
Sandra Barna, Valeria Conte, Francesco Cordoni, Marta Missiaggia, Fada Guan, Anatoly Rozenfeld, Gustavo Santa Cruz, Tatsuhiko Sato, Giuseppe Schettino, Chiara La Tessa   +9 more
wiley   +1 more source

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
P2X7R regulates the nucleoplasmic translocation of HuR, thereby enhancing the stability of the E3 ubiquitin ligase TRIM26. TRIM26 directly binds to NR4A1 and promotes its ubiquitination, thereby suppressing mitophagy and increasing reactive oxygen species (ROS) production.
Yixin Zhou, Xin Zhong, Zhijie Mao, Yunxuan Chen, Jincheng Xing, Jiaxu Shen, Wenli Zhang, Ji Zhang, Jiaxuan Mei, Zhentong Yang, Zhuoqun Wang, Bozhi Ye, Jiahui Lin, Yonghua Wang, Zhouqing Huang   +14 more
wiley   +1 more source