Results 101 to 110 of about 109,847 (333)

Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

ACS Medicinal Chemistry Letters, 2019
The synthesis, characterization, and biological evaluation of a series of compounds incorporating two or three benzoxaborole moieties is reported. Three different synthetic strategies were used to explore within this series as much chemical space as ...
Adèle Larcher, A. Nocentini, C. Supuran, J. Winum, A. van der Lee, J. Vasseur, D. Laurencin, Michael Smietana   +7 more
semanticscholar   +1 more source

Ketogenic diet therapy for the treatment of pediatric epilepsy

Epileptic Disorders, EarlyView.
Abstract In 1921, the classic ketogenic diet was created at the Mayo Clinic in Rochester, Minnesota to treat epilepsy in children and adults. Over a century later, it is a widely used, standard‐of‐care therapy for typically treatment‐resistant epilepsy worldwide.
Babitha Haridas, Alexander Testino, Eric H. Kossoff   +2 more
wiley   +1 more source

Hydrolysis of Cephalexin and Meropenem by New Delhi Metallo $β$-Lactamase: Substrate Protonation Mechanism is Drug Dependent [PDF]

, 2017
Emergence of antibiotic resistance due to New Delhi Metallo $\beta$-lactamase (NDM-1) bacterial enzymes is of great concern due to their ability to hydrolyze wide range of antibiotics. Efforts are ongoing to obtain the atomistic details of the hydrolysis mechanism in order to develop novel drugs and inhibitors against NDM-1.
arxiv   +1 more source

Hyperbaric Oxygen Regulates Tumor pH to Boost Copper‐Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells

Exploration, EarlyView.
Hypoxia and acidic microenvironments are characteristic features of solid tumors, driving tumor growth, drug resistance, and metastasis. To address these issues, we combined hyperbaric oxygen therapy with rational designed hydroxyethyl starch‐doxorubicin‐copper nanoparticles to modulate the acidic microenvironment of tumors while enhancing the efficacy
Qingyuan Deng, Ao Hua, Shiyou Li, Zhijie Zhang, Xiang Chen, Qiang Wang, Xing Wang, Zhiqin Chu, Xiangliang Yang, Zifu Li   +9 more
wiley   +1 more source

Calcium chelate is as effective as phosphite in controlling Phytophthora root rot in glasshouse trials

Plant Pathology, Volume 72, Issue 1, Page 112-119, January 2023., 2023
Calcium chelate is as effective as phosphite in controlling Phytophthora root rot in glasshouse trials. Abstract Species in the genus Phytophthora cause significant economic losses in crops and damage to forests and natural ecosystems worldwide.
Mohammed Y. Khdiar, Treena I. Burgess, Paul A. Barber, Giles E. St.J. Hardy   +3 more
wiley   +1 more source

Mucin-inspired, high molecular weight virus binding inhibitors show biphasic binding behavior to influenza A viruses [PDF]

arXiv, 2020
Multivalent virus binding inhibitors are a promising new class of antivirals, preventing virus infection of cells by inhibiting the first step in the viral infection cycle - binding of viruses to the cell surface. The design of multivalent virus binding inhibitors is complex as many properties, such as inhibitor size and functionalization with virus ...
arxiv  

Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack, Camila B. Carballo, Erica J. Secor, Scott A. Rodeo, Heidi L. Reesink   +4 more
wiley   +1 more source

Initiation of bivalve shell calcification under ocean acidification: integrating insights from shell to cell

Limnology and Oceanography Letters, EarlyView.
Abstract The formation of initial bivalve shell is sensitive to ocean acidification, encoding the basis of shell formation and environmental information. Here, we demonstrated how the initial shell building processes were affected under various acidified conditions.
Yang Xu, Fortunatus Masanja, Yuewen Deng, Yong Liu, Liqiang Zhao   +4 more
wiley   +1 more source

Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies

Results in Chemistry, 2022
A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas.
Imran Shafique, Aamer Saeed, Atteeque Ahmed, Ghulam Shabir, Anwar Ul-Hamıd, Ajmal Khan, Burak Tüzün, Mahinur Kirici, Parham Taslimi, Muhammad Latif   +9 more
doaj  

Carboxyl Carbon Quantum Dots: a Novel Type of Environmental-Friendly Scale Inhibitor [PDF]

arXiv, 2018
In this work, we demonstrate high inhibition efficiency of carboxyl carbon quantum dots (CCQDs) for the first time. The as-prepared CCQDs have excellent scale inhibition performance for calcium sulfate and barium sulfate. With static test of scale inhibition within temperature below 80 degrees, the anti-scaling efficiency can reach 100 % with low ...
arxiv