Pharmacogenetics of ophthalmic topical β-blockers [PDF]
, 2008 Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A. +4 more
core +1 more source
International Journal of Cancer, EarlyView.What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies +12 more
wiley +1 more source
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
Molecules, 2016 Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions.
Anastasia Karioti +2 more
doaj +1 more source
Subcellular distribution of carbonic anhydrase in Solanum tuberosum L. leaves [PDF]
, 1996 The intracellular compartmentation of carbonic anhydrase (CA; EC 4.2.1.1), an enzyme that catalyses the reversible hydration of CO2 to bicarbonate, has been investigated in potato (#Solanum tuberosum$ L.) leaves.
Cuiné, S. +5 more
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In Memoriam: W. King Engel, MD (1930–2025)
Annals of Neurology, EarlyView.
Marinos C. Dalakas, Steven P. Ringel
wiley +1 more source
Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis
Journal of Periodontology, EarlyView.Abstract Background Although age and smoking influence the periodontal proteome, their impact on subgingival biomarkers for diagnosing periodontitis remains unclear. This multicenter study assessed their influence on subgingival proteins for disease detection.
Triana Blanco‐Pintos +8 more
wiley +1 more source
An overview of carbohydrate-based carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Carbonic anhydrases (CAs) are metalloenzymes responsible for the reversible hydration of carbon dioxide to bicarbonate, a fundamental reaction involved in various physiological and pathological processes.
Doretta Cuffaro +2 more
doaj +1 more source
Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties [PDF]
, 2015 A series of sulfamates were synthesized using as lead compound SLC-0111, a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor in Phase I clinical trials.
Balboni, Gianfranco +5 more
core +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis [PDF]
, 2017 We cloned, expressed, purified, and determined the kinetic constants of the recombinant α-carbonic anhydrase (rec-MgaCA) identified in the mantle tissue of the bivalve Mediterranean mussel, Mytilus galloprovincialis.
Alasmary, Fatmah A. S. +11 more
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