Results 111 to 120 of about 109,847 (333)

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the α-class enzyme from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were recently reported.
Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Júnior, E. D. dos Santos, C. Supuran   +4 more
semanticscholar   +1 more source

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings

Pediatric Discovery, EarlyView.
Abstract Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases.
Ethan S. Wong, Daniel A. Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong‐Chuan He, Russell R. Reid, Lewis S. Shi, Michael J. Lee, Yi Zhu   +13 more
wiley   +1 more source

Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates

PROTEOMICS, EarlyView.
ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre, Jens Hamar, Monica B. Urias, Dietmar Kültz   +3 more
wiley   +1 more source

The Diagnostic Value of Plasma Small Extracellular Vesicle‐Derived CAIX Protein in Prostate Cancer and Clinically Significant Prostate Cancer: A Study on Predictive Models

The Prostate, EarlyView.
ABSTRACT Background Current diagnostic tools are inaccurate and not specific to prostate cancer (PCa) diagnosis. Cancer‐derived small extracellular vehicles (sEVs) play a key role in intercellular communication. In this study, we examined the diagnostic value of plasma sEV‐derived carbonic anhydrase IX (CAIX) protein for PCa and clinically significant ...
Haotian Chen, Bairen Pang, Zhihan Liu, Benjie Li, Qi Wang, Baokun Fan, Meng Han, Jie Gong, Cheng Zhou, Yingzhi Chen, Yong Li, Junhui Jiang   +11 more
wiley   +1 more source

Exploring the binding potential of natural compounds to carbonic anhydrase of cyanobacteria through computer-based simulations

Discover Applied Sciences
Cyanobacteria in water bodies cause harmful cyanobacterial blooms, releasing toxins that degrade water quality and cause health issues. Common Harmful Algal Bloom-related disorders (HABs) include neurotoxic shellfish poisoning, ciguatera poisoning ...
Archana Padhiary, Showkat Ahmad Mir, Aiswarya Pati, Binata Nayak   +3 more
doaj   +1 more source

THE EFFECTS OF THE CARBONIC ANHYDRASE INHIBITOR “6063” ON ELECTROLYTES AND ACID-BASE BALANCE IN TWO NORMAL SUBJECTS AND TWO PATIENTS WITH RESPIRATORY ACIDOSIS 1 [PDF]

, 1953
Judith Nadell, Helen Kalinsky
openalex   +1 more source

Silkworm Silk Can Become a High‐Strength and Super‐Toughness Spider‐Silk‐Like Fiber: Multipathway Engineering Strategies and Applications

Small Structures, EarlyView.
This article compares the mechanical properties of silkworm and spider silk by emphasizing their distinct hierarchical microstructures. Recent progress in multipathway engineering strategies that enhance silkworm silk's strength and elasticity is reviewed.
Mengqi Wang, Zhiming Du, Aixin Tong, Yu Zhang, Yuxin Luo, Zhicheng Shi, Sijie Qiao, Zhiyu Huang, Annan He, Xiachao Chen, Guizhen Ke, Qing Liu, Weilin Xu, Fengxiang Chen   +13 more
wiley   +1 more source

Carbonic anhydrase II simulated with a universal neural network potential [PDF]

arXiv
The carbonic anhydrase II enzyme (CA II) is one of the most significant enzymes in nature, reversibly converting CO$_2$ to bicarbonate at a remarkable rate. The precise mechanism it uses to achieve this rapid turnover remains unclear due to our inability to directly observe or simulate the full process dynamically.
arxiv  

(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies

BMC Chemistry
Human Carbonic Anhydrase inhibitors (CAIs) have been clinically used to treat a variety of disorders, such as cancer, obesity, haemolytic anaemia, glaucoma, retinopathy, and epilepsy.
Aftab Ahmed, Sara Ilyas, Pervaiz Ali Channar, Syeda Abida Ejaz, Aamer Saeed, Seema Sarwar Ghumro, Mohamad Ahmad Saleem Khasawneh, Shagufta Naz Channar, Rabail Ujan, Qamar Abbas, Tuncer Hökelek   +10 more
doaj   +1 more source