Results 31 to 40 of about 109,847 (333)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm +7 more
doaj +1 more source
Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
Metabolites, 2020 The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of anticancer therapies.
A. Angeli +14 more
semanticscholar +1 more source
The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan +3 more
doaj +1 more source
Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I
Oftalʹmologiâ, 2020 Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively.
N. I. Kurysheva
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.
M. Kciuk +6 more
semanticscholar +1 more source
Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems
Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023 This review discusses dynamically responsive self‐assembling peptide‐based nano‐drug systems, including the stimulation response, strategy of biomimicry, subcellular internalization, and the applications of peptide nano‐drug materials, and concludes with a brief outlook of their challenges and opportunities in clinical translation.
Yuhan Wang +6 more
wiley +1 more source
Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors
Journal of Experimental Pharmacology, 2020 Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues.
C. Supuran
semanticscholar +1 more source
Kidney and Blood Pressure Research, 1987 The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
Robert J. Alpern +2 more
openaire +3 more sources
Biomedical applications of silk and its role for intervertebral disc repair
JOR SPINE, Volume 5, Issue 4, December 2022., 2022 For years, researchers have been seeking a suitable biomaterial to repair and/or regenerate the intervertebral disc (IVD) and a promising candidate to fill this gap could be the application of silk. Therefore, this review aims to elaborate on the different origins from which silk is harvested, the characteristics of each silk type and how it can be ...
Andreas S. Croft +6 more
wiley +1 more source
Management of glaucoma in pregnancy: risks or choices, a dilemma? [PDF]
International Journal of Ophthalmology, 2016 The treatment of glaucoma in and around pregnancy offers the unique challenge of balancing the risk of vision loss to the mother as against the potential harm to the fetus or newborn. Most anti-glaucoma drugs (i.e. beta-blockers, prostaglandin analogues,
Harinder Singh Sethi +2 more
doaj +1 more source