Results 51 to 60 of about 109,847 (333)

Plasma proteomic signature of decline in gait speed and grip strength

Aging Cell, Volume 21, Issue 12, December 2022., 2022
Several plasma proteins were associated with physical function decline in adults from middle to older age, including GDF‐15, pleiotrophin, and TIMP‐1 for gait speed decline, and CA III, CDON, and SMOC1 for grip strength decline. These novel proteomic biomarkers may by explored as future mechanisms and targets for age‐related functional decline ...
Xiaojuan Liu, Stephanie Pan, Vanessa Xanthakis, Ramachandran S. Vasan, Bruce M. Psaty, Thomas R. Austin, Anne B. Newman, Jason L. Sanders, Chenkai Wu, Russell P. Tracy, Robert E. Gerszten, Michelle C. Odden   +11 more
wiley   +1 more source

A topological selection of folding pathways from native states of knotted proteins [PDF]

arXiv, 2021
Understanding the biological function of knots in proteins and their folding process is an open and challenging question in biology. Recent studies classify the topology and geometry of knotted proteins by analysing the distribution of a protein's planar projections using topological objects called knotoids.
arxiv  

Carbonic anhydrase inhibitory properties of some uracil derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI
Emir Alper Türkoğlu, Murat Şentürk, Claudiu T. Supuran, Deniz Ekinci   +3 more
doaj   +1 more source

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Platelets, 2020
Carbonic anhydrase (CA) inhibitors have a long history of safe clinical use as mild diuretics, in the treatment of glaucoma and for altitude sickness prevention.
Ejaife O. Agbani, Xiaojuan Zhao, Christopher M. Williams, Riyaad Aungraheeta, Ingeborg Hers, Erik R. Swenson, Alastair W. Poole   +6 more
doaj   +1 more source

Impact of HAC evolution on the formation of small hydrocarbons in the Orion Bar and the Horsehead PDRs [PDF]

, 2022
We study evolution of hydrogenated amorphous carbon (HAC) grains under harsh UV radiation in photo-dissociation regions (PDRs) near young massive stars. Our aim is to evaluate the impact of the HAC grains on formation of observed small hydrocarbons: C$_2$H, C$_2$H$_2$, C$_3$H$^+$, C$_3$H, C$_3$H$_2$, C$_4$H, in PDRs. We developed a microscopic model of
arxiv   +1 more source

SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME [PDF]

Química Nova
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde ...
Mumtaz Hussain, Pervaiz Ali Channar, Aisha A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Zahid Hussain, Ghulam Abbas Kandhro, Hafiz Muhammad Attaullah, Rabail Ujhan, Mushtaque Ali Jakhrani, Aamer Saeed, Qamar Abbas, Laith Abualigah   +12 more
doaj   +1 more source

Complementary experimental methods to obtain thermodynamic parameters of protein ligand systems [PDF]

arXiv, 2022
In recent years, thermophoresis has emerged as a promising tool for quantifying biomolecular interactions. The underlying physical effect is still not understood. To gain deeper insight, we investigate whether non-equilibrium coefficients can be related to equilibrium properties.
arxiv  

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
We report the synthesis and characterisation of a novel series of triazole benzenesulfonamide derivatives, which incorporate the general pharmacophore associated with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.
Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran   +5 more
doaj   +1 more source

Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes

Arabian Journal of Chemistry, 2017
This study focused on the synthesis and characterization of hydrazide ligands and their respective Pd(II) complexes and used high throughput screening to determine their α-glucosidase and carbonic anhydrase II enzyme inhibition activities.
Qurrat-ul-Ain, Uzma Ashiq, Rifat Ara Jamal, Muhammad Saleem, Mohammad Mahroof-Tahir   +4 more
doaj   +1 more source

Medium dependence of asphaltene agglomeration inhibitor efficiency [PDF]

Energy & Fuels vol.22, 2008, pp 1917 - 1922;, 2007
Applying chemical additives (molecule inhibitors or dispersants) is one of the common ways to control asphaltene agglomeration and precipitation. However, it is not clear why at some conditions the synthetic flocculation inhibitors as well as resins not only do not inhibit the asphaltene agglomeration,, they may also promote it, and why the increasing ...
arxiv   +1 more source