Results 241 to 250 of about 7,953 (283)
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Future Medicinal Chemistry, 2018
Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, etc.) but the activators were less investigated till recently.
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Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, etc.) but the activators were less investigated till recently.
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2000
In contrast to animal and plant carbonic anhydrases, relatively little is known about carbonic anhydrases in bacteria. Carbonic anhydrase activity has been well documented in a few bacterial species and its presence has been inferred on the basis of gene sequence homologies in several others, but their functions are generally not known.
E I, Kozliak +3 more
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In contrast to animal and plant carbonic anhydrases, relatively little is known about carbonic anhydrases in bacteria. Carbonic anhydrase activity has been well documented in a few bacterial species and its presence has been inferred on the basis of gene sequence homologies in several others, but their functions are generally not known.
E I, Kozliak +3 more
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1987
The ṗroperties of Carbonic Anhydrase, the enzyme which catalyzes the CO2 hydration and HCO3 - dehydration, are reviewed. The mechanism is discussed in details in terms of Zn-OH attacking CO2 to give rise to HCO3 which is then released after H20 uptake. H+ is then released. The inhibition mechanism is also discussed.
BERTINI, IVANO +2 more
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The ṗroperties of Carbonic Anhydrase, the enzyme which catalyzes the CO2 hydration and HCO3 - dehydration, are reviewed. The mechanism is discussed in details in terms of Zn-OH attacking CO2 to give rise to HCO3 which is then released after H20 uptake. H+ is then released. The inhibition mechanism is also discussed.
BERTINI, IVANO +2 more
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Bioorganic & Medicinal Chemistry Letters, 2010
Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all organisms, catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically for decades for various classes of diuretics and systemically acting antiglaucoma agents.
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Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all organisms, catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically for decades for various classes of diuretics and systemically acting antiglaucoma agents.
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2019
Among the seven different classes of carbonic anhydrases (CAs), the Ζ-class represents a very interesting one due to the biochemical peculiarity of CDCA1, which is the most investigated representative. In fact, CDCA1 is a cambialistic enzyme being able to naturally exchange Zn(II) with Cd(II) and vice versa, within its catalytic site.
Langella, E. +4 more
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Among the seven different classes of carbonic anhydrases (CAs), the Ζ-class represents a very interesting one due to the biochemical peculiarity of CDCA1, which is the most investigated representative. In fact, CDCA1 is a cambialistic enzyme being able to naturally exchange Zn(II) with Cd(II) and vice versa, within its catalytic site.
Langella, E. +4 more
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Carbonic Anhydrase in Bacteria
Nature, 1963THE richest source of carbonic anhydrase is mammalian erythrocytes. It is also found in the pancreas, gastric mucosa, and kidney in fairly high concentration. Carbonic anhydrase has also been found localized in the cytoplasm of plant leaf tissue1–4. A survey of the literature revealed no report of the occurrence of microbial carbonic anhydrases.
F P, VEITCH, L C, BLANKENSHIP
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Carbonic Anhydrase in the Cornea
Acta Physiologica Scandinavica, 1974AbstractCarbonic anhydrase activity in the corneas of adult man, human fetus, monkey, rabbit, rat, cow, pig and American bullfrog was examined by the histochemical method of Hansson. In all species the endothelial cells were intensely and distinctly stained for carbonic anhydrase activity.
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2016
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the α-, β-, and/or γ-CA families. In the last decade enzymes from Neisseria spp., Helicobacter pylori, Escherichia coli, Mycobacterium tuberculosis, Brucella spp ...
Capasso C., Supuran C. T.
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Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the α-, β-, and/or γ-CA families. In the last decade enzymes from Neisseria spp., Helicobacter pylori, Escherichia coli, Mycobacterium tuberculosis, Brucella spp ...
Capasso C., Supuran C. T.
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Novel Carbonic Anhydrase Inhibitors
Future Medicinal Chemistry, 2021Abstract
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Nature, 1947
IN contrast to the wealth of information concerning carbonic anhydrase in the animal kingdom, there have been few reports of the occurrence of this enzyme in the plant kingdom1. It seemed desirable, therefore, briefly to describe the following observations made in the course of work on the enzyme in animal tissues.
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IN contrast to the wealth of information concerning carbonic anhydrase in the animal kingdom, there have been few reports of the occurrence of this enzyme in the plant kingdom1. It seemed desirable, therefore, briefly to describe the following observations made in the course of work on the enzyme in animal tissues.
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