Results 241 to 250 of about 2,925,002 (305)

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

European Journal of Immunology, Volume 56, Issue 9, September 2026.
(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib   +8 more
wiley   +1 more source

Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction. [PDF]

ACS Pharmacol Transl Sci
Elzahhar PA, Nematalla HA, Abouayana MA, El Ashry ESH, Balbaa M, Petreni A, Nassra R, Yassin HA, Kamel YN, Elrewiny MA, Agami MA, Makkar M, Sai M, Merk D, Labib HF, Spagnuolo R, Naldi M, Bartolini M, El-Hawash SA, Supuran CT, Belal ASF, El-Yazbi AF.   +21 more
europepmc   +1 more source

Stereoselective Construction of Benzo‐Fused Tetrahydropyrrole Thiazines From Saccharin

European Journal of Organic Chemistry, Volume 29, Issue 33, 1 September 2026.
Saccharin was used as a template to construct a series of 10a‐substituted, benzo‐fused, pyrrolo thiazinone dioxides. Thereafter, diastereo‐divergent 10‐keto reduction gave either diastereomeric alcohol in a process that did not rely on the substituent at 10a's identity.
Seanán Doyle, Matthew Kiernan, Jordan Smyth, Ajay Mathew, Conor J. Crawford, Julia Bruno‐Colmenarez, Patrick J. Guiry, Aisha Khalifa, Paul Evans   +8 more
wiley   +1 more source

Unraveling the Potential of Amino‑, Acylamino‑, and Ureido-Substituted 3<i>H</i>‑1,2-Benzoxaphosphepine 2‑Oxides toward Nanomolar Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII. [PDF]

ACS Med Chem Lett
Balašova A, Pustenko A, Angeli A, Andreucci E, Biagioni A, Nocentini A, Carta F, Supuran CT, Žalubovskis R.   +8 more
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Streamlining heterologous expression of top carbonic anhydrases in Escherichia coli: bioinformatic and experimental approaches. [PDF]

Microb Cell Fact
Wei H, Lunin VV, Alahuhta M, Himmel ME, Huang S, Bomble YJ, Zhang M.   +6 more
europepmc   +1 more source

4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells. [PDF]

J Med Chem
Eldehna WM, Fares M, Bonardi A, Avgenikos M, Baselious F, Schmidt M, Al-Warhi T, Abdel-Aziz HA, Rennert R, Peat TS, Supuran CT, Wessjohann LA, Ibrahim HS.   +12 more
europepmc   +1 more source

Overexpression of native carbonic anhydrases increases carbon conversion efficiency in the methanotrophic biocatalyst <i>Methylococcus capsulatus</i> Bath. [PDF]

mSphere
Lee SA, Henard JM, Alba RAC, Benedict CA, Mayes TA, Henard CA.   +5 more
europepmc   +1 more source

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Biomedical applications of prokaryotic carbonic anhydrases

Expert Opinion on Therapeutic Patents, 2018
Introduction: The hydration/dehydration of CO2 catalyzed by carbonic anhydrases (CAs, EC 4.2.1.1) is a crucial physiological reaction for the survival of all living organisms because it is connected with numerous biosynthetic and biochemical pathways ...
Clemente Capasso, Claudiu Supuran
exaly   +2 more sources