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Introduction to the carbonic anhydrases
2000Since the discovery, almost 70 years ago, of the enzyme carbonic anhydrase (CA), which plays an important role in the red blood cell by catalyzing the hydration of carbon dioxide (CO2 + H2O ↔ HCO– 3+ H+), a fascinating and complex story has unfolded of three enzyme families performing numerous functions in many different organisms.
W R, Chegwidden, N D, Carter
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Perspectives on carbonic anhydrase
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2010In the years since Larimer and Schmidt-Nielsen published their examination of red blood cell (RBC) carbonic anhydrase (CA) activities as a function of body mass in mammals, our knowledge of CA has expanded dramatically. We are now aware of the diversity of CA isoforms and their implication in a wide array of physiological processes.
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Carbonic Anhydrases An Overview
Current Pharmaceutical Design, 2008Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes all over the phylogenetic tree, with at least 4 distinct gene families encoding for them. At least 16 different alpha-CA isoforms were isolated in mammals, where these enzymes play crucial physiological roles.
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Carbonic Anhydrase II Deficiency
Clinical Orthopaedics and Related Research, 1993Carbonic anhydrase (CA) isoenzyme II deficiency--formerly called the syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification--is an autosomal recessive "inborn error of metabolism" that has disclosed important insight concerning osteoclast function.
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Carboxysomal Carbonic Anhydrases
2013Cyanobacteria and some chemoautotrophic bacteria enhance their carbon fixation efficiency by actively concentrating bicarbonate within their cytosol. However, converting bicarbonate into carbon dioxide - the form required by RubisCO - would result in its rapid escape through cellular membranes.
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An overview on the recently discovered iota-carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021Alessio Nocentini +2 more
exaly
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1977
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