Results 1 to 10 of about 7,932 (198)

Synthesis and Anti-Tumor Evaluation of Carboranyl BMS-202 Analogues—A Case of Carborane Not as Phenyl Ring Mimetic [PDF]

Molecules
Carborane is considered a three-dimensional mimetic of phenyl rings in medicinal chemistry. BMS-202 is a potent PD-L1 inhibitor that can block the PD-L1/PD-1 interaction and restore the immune response to cancer cells.
Changxian Yuan, Chaofan Li, Chenyang Ma, Yuzhe Lin, Linyuan Wang, Guanxiang Hao, Yirong Zhang, Hongjing Li, Yuan Li, Yu Zhao, Nan Sun, Tiezheng Chen, Zhiguang Zhang, Dengfeng Cheng, Sinan Wang   +14 more
doaj   +2 more sources

Crystal structure of 1-butyl-2,3-dimethylimidazolium dicarba-7,8-nido-undecaborate [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title molecular salt, C9H17N2+·C2H12B9−, the carborane cage has a bridging B—H—B bond on the open B3C2 face. The butyl side chain of the cation adopts an extended conformation [C—C—C—C = 179.6 (1)°].
M. J. Klemes, L. Soderstrom, J. L. Hunting, A. S. Larsen   +3 more
doaj   +3 more sources

Icosahedral metallacarborane/carborane species derived from 1,1′-bis(o-carborane) [PDF]

Dalton Transactions, 2015
We thank ORSAS (GS) and the EPSRC (DE and DMcK supported by project EP/E02971X/1, WYM supported by project EP/I031545/1) for funding.Examples of singly-metallated derivatives of 1,1[prime or minute]-bis(o-carborane) have been prepared and ...
Chan, Antony P Y, Ellis, David, Jourdan, Laure, Leube, Bernhard T, Macgregor, Stuart A., Man, Wing Y., McKay, David, Palmero Palos, Cesar, Rosair, Georgina M., Thiripuranathar, Gobika, Welch, Alan J.   +10 more
core   +4 more sources

Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy [PDF]

Nanomaterials
Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues.
Zhangali A. Bekbol, Kairat A. Izbasar, Alexander Zaboronok, Lana I. Lissovskaya, Haolan Yang, Yuriy Pihosh, Eiichi Ishikawa, Rafael I. Shakirzyanov, Ilya V. Korolkov   +8 more
doaj   +2 more sources

Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane [PDF]

Beilstein Journal of Organic Chemistry
A new series of o-carborane-fused pyrazoles has been recently successfully synthesized. This fusion was expected to create a hybrid 3D/2D aromatic system, combining the 3D aromaticity of o-carborane with the 2D aromaticity of pyrazole. However, while the
Zahra Noori, Miquel Solà, Clara Viñas, Francesc Teixidor, Jordi Poater   +4 more
doaj   +2 more sources

Structure-Activity Relationships of closo- and nido-Carborane Erlotinib Analogs: Lipophilicity as a Key Modulator of Anti-Glioma Activity [PDF]

Pharmaceuticals
Background/Objectives: To enhance the anti-glioma activity of erlotinib, we previously developed a series of carborane-based analogs exploiting the concept of three-dimensional bioisosterism.
Belén Dávila, Pablo Vignolo, Martina Silvarrey, Andrés Benítez, Juliana González Schmidt, Carmela de Arteaga Guidotti, María Fernanda García, Hugo Cerecetto, Marcos Couto   +8 more
doaj   +2 more sources

Liquid Carbon-Boron Cluster Additives for Mixed Amine-50 [PDF]

Molecules
Boron-containing compounds, known for their high calorific value, can significantly enhance the energy density of traditional liquid propellants. Through precise chemical modification of the C-H bonds in ortho-carborane, a novel liquid cluster material ...
Xiaogang Mu, Shenghui Wang, Fanzhi Yang, Hao Li   +3 more
doaj   +2 more sources

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Molecular Therapy: Oncolytics, 2022
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery.
Yu Chen, Fukuan Du, Liyao Tang, Jinrun Xu, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Qinglian Wen, Chi Hin Cho, Zhangang Xiao   +10 more
doaj   +1 more source

Synthesis, Crystal Structure, and Some Transformations of 9,12-Dichloro-ortho-Carborane

Crystals, 2022
Reaction of ortho-carborane with anhydrous AlCl3 in chloroform results in a mixture of 9-chloro, 9,12-dichloro, and 8,9,12-trichloro derivatives with 9,12-dichloro-ortho-carborane being the main product. Molecular crystal structure of 9,12-dichloro-ortho-
Sergey A. Anufriev, Sergey V. Timofeev, Olga B. Zhidkova, Kyrill Yu. Suponitsky, Igor B. Sivaev   +4 more
doaj   +1 more source

Carborane photochromism: a fatigue resistant carborane switch

Chemical Communications, 2021
A dithienylethene molecule involving carborane clusters shows remarkable fatigue resistance and high contrast visual colour changes when irradiated with alternating ultraviolet and visible light.
Chong Li, Matthew P. Aldred, Rachel A. Harder, Ying Chen, Dmitry S. Yufit, Ming-Qiang Zhu, Mark A. Fox   +6 more
openaire   +5 more sources