Results 61 to 70 of about 235,116 (346)
Frontiers in Immunology, 2019 Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma of pancreatic ductal adenocarcinomas and besides their pathological release of extracellular matrix proteins, they are also perceived as key contributors to ...
L. Gorchs +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Anaplastic Carcinoma of the Pancreas: Clinical and Morphological Characteristics
Case Reports in Gastroenterology, 2020 Anaplastic pancreatic carcinoma is a very rare histological subtype of pancreatic cancer, which is characterized by a more aggressive course than for conventional ductal adenocarcinoma.
Valery I. Podzolkov +5 more
doaj +1 more source
Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core +1 more source
Gastroenterology, 2018 Pancreatic ductal adenocarcinoma (PDAC) is resistant to T-cell-mediated immunotherapy. We engineered T cells to transiently express a messenger RNA encoding a chimeric antigen receptor (CAR) specific for mesothelin, a protein that is overexpressed by ...
G. Beatty +14 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
生物医学转化Objective To investigate the mechanism underlying primary cilia loss in ductal carcinomas (breast, pancreatic, and cholangiocarcinoma). Methods Transcriptomic data from ductal carcinomas (breast ductal carcinoma, pancreatic ductal adenocarcinoma ...
Li Zhengyang +7 more
doaj +1 more source
Pancreatic Ductal Carcinoma Risk Associated With Hereditary Cancer-Risk Genes
JNCI: Journal of the National Cancer Institute, 2022 AbstractBackgroundAlthough several hereditary cancer predisposition genes have been implicated in pancreatic ductal adenocarcinoma (PDAC) susceptibility, gene-specific risks are not well defined and are potentially biased because of the design of previous studies.
Anna Gardiner +9 more
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecules, 2022 Pancreatic carcinoma still represents one of the most lethal malignant diseases in the world although some progress has been made in treating the disease in the past decades.
Aleksandra Krstic +5 more
doaj +1 more source