Results 11 to 20 of about 1,572 (155)

Secondary Compounds in Milkweed Nectar Negatively Impact Thermal Tolerance in Bumble Bees. [PDF]

Ecol Evol
This study shows that exposure to cardenolide toxins in floral nectar impacts heat tolerance in bumble bees at field‐realistic doses. Various honeys, aside from milkweed honey, did not impact heat tolerance in these bees. These data suggest that compounds in their diet may impact resilience of bees to global warming and that milkweed‐specialists may be
Shippee R, Feuerborn C, Bradley A, Jahnke H, Hines HM.   +4 more
europepmc   +2 more sources

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Duckweeds: Model organisms for research on plant sterols and steroids. [PDF]

Plant Biol (Stuttg)
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
Klein J, Appenroth KJ, Sree KS.
europepmc   +2 more sources

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources

High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants

Data in Brief, 2020
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi, Mary Grace E. Guardian, Rebecca Dickman, Zhen Q. Wang   +3 more
doaj   +1 more source

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus Alternaria eureka 1E1BL1: Characterization and Cytotoxic Activities

Molecules, 2021
Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir, Çiğdem Karakoyun, Gamze Doğan, Gülten Kuru, Melis Küçüksolak, Hasan Yusufoğlu   +5 more
doaj   +1 more source

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

Differential accumulation of cardenolides from Asclepias curassavica by large milkweed bugs does not correspond to availability in seeds or biological activity on the bug Na+/K+-ATPase

Frontiers in Ecology and Evolution, 2023
Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago, Paola Rubiano-Buitrago, Shrikant Pradhan, Veit Grabe, Alfonso Aceves-Aparicio, Christian Paetz, Hannah M. Rowland   +6 more
doaj   +1 more source

Defence mitigation by predators of chemically defended prey integrated over the predation sequence and across biological levels with a focus on cardiotonic steroids

Royal Society Open Science, 2022
Predator–prey interactions have long served as models for the investigation of adaptation and fitness in natural environments. Anti-predator defences such as mimicry and camouflage provide some of the best examples of evolution.
Shabnam Mohammadi, Lu Yang, Matthew Bulbert, Hannah M. Rowland   +3 more
doaj   +1 more source

Characterization and Chromatographic Fingerprint Analysis of Traditional Wallflower Oil [PDF]

Research Journal of Pharmacognosy, 2021
Background and objective: Wallflower oil is made from the flowers of Erysimum cheiri (L.) Crantz which is a herb rich in cardenolide compounds. Wallflower oil was traditionally indicated for analgesic, anti-inflammatory, hair tonic, and wound healing ...
Ghazaleh Mosleh, Amir Azadi, Abdolali Mohagheghzadeh*   +2 more
doaj   +1 more source